Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery

Battersby, Bronwyn J., Lawrie, Gwendolyn A., Johnston, Angus P. R. and Trau, Matt (2002) Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery. Chemical Communications, 14: 1435-1441. doi:10.1039/b200038p


Author Battersby, Bronwyn J.
Lawrie, Gwendolyn A.
Johnston, Angus P. R.
Trau, Matt
Title Optical barcoding of colloidal suspensions: applications in genomics, proteomics and drug discovery
Journal name Chemical Communications   Check publisher's open access policy
ISSN 1359-7345
1364-548X
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1039/b200038p
Issue 14
Start page 1435
End page 1441
Total pages 7
Place of publication Cambridge, UK
Publisher The Royal Society of Chemistry
Language eng
Subject C1
270802 Diagnostic Applications
250103 Colloid and Surface Chemistry
730305 Diagnostic methods
780102 Physical sciences
Abstract The enormous amount of information generated through sequencing of the human genome has increased demands for more economical and flexible alternatives in genomics, proteomics and drug discovery. Many companies and institutions have recognised the potential of increasing the size and complexity of chemical libraries by producing large chemical libraries on colloidal support beads. Since colloid-based compounds in a suspension are randomly located, an encoding system such as optical barcoding is required to permit rapid elucidation of the compound structures. We describe in this article innovative methods for optical barcoding of colloids for use as support beads in both combinatorial and non-combinatorial libraries. We focus in particular on the difficult problem of barcoding extremely large libraries, which if solved, will transform the manner in which genomics, proteomics and drug discovery research is currently performed.
Keyword Chemistry, Multidisciplinary
Gene-expression
Combinatorial Libraries
Dna Microarrays
Multiplexed Analysis
Chemical Libraries
Flowmetrix System
Protein Arrays
Fluorescent
Peptide
Disease
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Wed, 15 Aug 2007, 03:30:20 EST