Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity

Gaiti, Federico, Jindrich, Katia, Fernandez-Valverde, Selene L., Roper, Kathrein E., Degnan, Bernard M. and Tanurdzic, Milos (2017) Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity. Elife, 6 . doi:10.7554/eLife.22194


Author Gaiti, Federico
Jindrich, Katia
Fernandez-Valverde, Selene L.
Roper, Kathrein E.
Degnan, Bernard M.
Tanurdzic, Milos
Title Landscape of histone modifications in a sponge reveals the origin of animal cis-regulatory complexity
Journal name Elife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2017-04-11
Year available 2017
Sub-type Article (original research)
DOI 10.7554/eLife.22194
Open Access Status DOI
Volume 6
Total pages 33
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Language eng
Subject 2800 Neuroscience
2700 Medicine
2400 Immunology and Microbiology
1300 Biochemistry, Genetics and Molecular Biology
Abstract Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity.
Formatted abstract
Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear when this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge Amphimedonqueenslandica, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repressive chromatin and transcriptional units marked by H3K4me3 that vary with levels of developmental regulation. Strikingly, Amphimedon enhancers are enriched in metazoan-specific microsyntenic units, suggesting that their genomic location is extremely ancient and likely to place constraints on the evolution of surrounding genes. These results suggest that the regulatory foundation for spatiotemporal gene expression evolved prior to the divergence of sponges and eumetazoans, and was necessary for the evolution of animal multicellularity.
Keyword Biology
Life Sciences & Biomedicine - Other Topics
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID FL110100044
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Biological Sciences Publications
 
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