Individualised medicine: why we need Bayesian dosing

Donagher, Joni, Martin, Jennifer H. and Barras, Michael A. (2017) Individualised medicine: why we need Bayesian dosing. Internal Medicine Journal, 47 5: 593-600. doi:10.1111/imj.13412

Author Donagher, Joni
Martin, Jennifer H.
Barras, Michael A.
Title Individualised medicine: why we need Bayesian dosing
Journal name Internal Medicine Journal   Check publisher's open access policy
ISSN 1445-5994
Publication date 2017-05-01
Sub-type Article (original research)
DOI 10.1111/imj.13412
Open Access Status Not yet assessed
Volume 47
Issue 5
Start page 593
End page 600
Total pages 8
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Subject 2724 Internal Medicine
Abstract Individualised drug dosing has been shown to improve patient outcomes and reduce adverse drug events. One method of individualised medicine is the Bayesian approach, which uses prior information about how the population responds to therapy, to inform clinicians about how a specific individual is responding to their current therapy. This information is then used to make changes to the dose. Studies using a Bayesian approach to adjust drug dosing have shown that clinicians are able to achieve a therapeutic range quicker than standard practice. If concentration is related to a pharmacodynamic end-point, this means that the drug will be more effective, and the side-effects will be minimised. Unfortunately, the software options to assist with Bayesian dosing in Australia are limited. The aims of this article are to demystify the concepts of Bayesian dosing, set the context of the Bayesian approach using reference to other dosing strategies and discuss its benefits over current dosing methods for a number of drugs. The article is targeted to medical and pharmacy clinicians, and there is a practical clinical case to demonstrate how this method could be used in everyday clinical practice.
Keyword Bayesian
Individualised drug dosing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Pharmacy Publications
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