Homeotic genes influence the axonal pathway of a Drosophila embryonic sensory neuron

Merritt, DJ and Whitington, PM (2002) Homeotic genes influence the axonal pathway of a Drosophila embryonic sensory neuron. International Journal of Developmental Biology, 46 4: 633-638.

Author Merritt, DJ
Whitington, PM
Title Homeotic genes influence the axonal pathway of a Drosophila embryonic sensory neuron
Journal name International Journal of Developmental Biology   Check publisher's open access policy
ISSN 0214-6282
Publication date 2002-01-01
Year available 2002
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 46
Issue 4
Start page 633
End page 638
Total pages 6
Place of publication Bilbao, Spain
Publisher UBC Press
Language eng
Subject C1
270502 Neurobiology
780105 Biological sciences
Abstract Each abdominal hemisegment of the Drosophila embryo has two sensory neurons intimately associated with a tracheal branch. During embryogenesis, the axons of these sensory neurons, termed the v'td2 neurons, enter the CNS and grow toward the brain with a distinctive pathway change in the third thoracic neuromere. We show that the axons use guidance cues that are under control of the bithorax gene complex (BX-C). Pathway defects in mutants suggest that a drop in Ultrabithorax expression permits the pathway change in the T3 neuromere, while combined Ultrabithorax and abdominal-A expression represses it in the abdominal neuromeres. We propose that the axons do not respond to a particular segmental identity in forming the pathway change; rather they respond to pathfinding cues that come about as a result of a drop in BX-C expression along the antero-posterior axis of the CNS.
Keyword Developmental Biology
Neuronal Identity
Axonal Guidance
Homeosis
Drosophila
Pns
Central-nervous-system
Bithorax Complex
Ultrabithorax Proteins
Segmentation
Cns
Melanogaster
Organization
Repression
Expression
Products
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Biological Sciences Publications
 
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Created: Wed, 15 Aug 2007, 03:26:38 EST