Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis

Spiller, Cassy M. and Bowles, Josephine (2017) Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis. International Journal of Biochemistry & Cell Biology, 86 22-25. doi:10.1016/j.bioce1.2017.03.004


Author Spiller, Cassy M.
Bowles, Josephine
Title Germ cell neoplasia in situ: the precursor cell for invasive germ cell tumors of the testis
Journal name International Journal of Biochemistry & Cell Biology   Check publisher's open access policy
ISSN 1357-2725
1878-5875
Publication date 2017-05-01
Sub-type Article (original research)
DOI 10.1016/j.bioce1.2017.03.004
Open Access Status Not yet assessed
Volume 86
Start page 22
End page 25
Total pages 4
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon Press
Language eng
Formatted abstract
Germ cell neoplasia in situ is the non-invasive precursor cell of origin for type II testicular germ cell tumors. It has long been postulated that germ cell neoplasia in situ is derived from defective germ cell development during embryonic life, and although it is impossible to trace in vivo the progression from fetal germ cell to germ cell neoplasia in situ to tumor, there is a large volume of evidence supporting this theory. Current studies focus on understanding how germ cell neoplasia in situ forms, how these cells are activated at puberty and how they transform to invasive tumors of various subtypes. Such information is informing novel diagnostic and therapeutic options.
Keyword Germ cell neoplasia in situ
Testicular germ cell tumor
Testis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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