Substance misuse in patients with schizophrenia: epidemiology and management

Kavanagh, DJ, McGrath, J, Saunders, JB, Dore, G and Clark, D (2002) Substance misuse in patients with schizophrenia: epidemiology and management. Drugs, 62 5: 743-755. doi:10.2165/00003495-200262050-00003


Author Kavanagh, DJ
McGrath, J
Saunders, JB
Dore, G
Clark, D
Title Substance misuse in patients with schizophrenia: epidemiology and management
Journal name Drugs   Check publisher's open access policy
ISSN 0012-6667
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.2165/00003495-200262050-00003
Volume 62
Issue 5
Start page 743
End page 755
Total pages 13
Editor T. M Speight
J Turnidge
Place of publication Auckland, New Zealand
Publisher Adis International
Collection year 2002
Language eng
Subject C1
321021 Psychiatry
730211 Mental health
Abstract Substance misuse in individuals with schizophrenia is very common, especially in young men, in communities where use is frequent and in people receiving inpatient treatment. Problematic use occurs at very low intake levels, so that most affected people are not physically dependent (with the exception of nicotine). People with schizophrenia and substance misuse have poorer symptomatic and functional outcomes than those with schizophrenia alone. Unless there is routine screening, substance misuse is often missed in assessments. Service systems tend to be separated, with poor inter-communication, and affected patients are often excluded from services because of their comorbidity. However, effective management of these disorders requires a fully integrated approach because of the close inter-relationship of the disorders. Use of atypical antipsychotics may be especially important in this population because of growing evidence (especially on clozapine and risperidone) that nicotine smoking, alcohol misuse and possibly some other substance misuse is reduced. Several pharmacotherapies for substance misuse can be used safely in people with schizophrenia, but the evidence base is small and guidelines for their use are necessarily derived from experience in the general population.
Keyword Pharmacology & Pharmacy
Toxicology
Severe Mental-illness
Treatment-resistant Schizophrenia
Tardive-dyskinesia
Smoking Cessation
Use Disorder
Psychiatric-symptoms
Nicotine Withdrawal
Cigarette-smoking
Clinical-trial
Drug-abuse
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 03:24:44 EST