The diagnosis of equine insulin dysregulation

Bertin, F. R. and de Laat, M. A. (2017) The diagnosis of equine insulin dysregulation. Equine Veterinary Journal, 49 5: 570-576. doi:10.1111/evj.12703

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Author Bertin, F. R.
de Laat, M. A.
Title The diagnosis of equine insulin dysregulation
Journal name Equine Veterinary Journal   Check publisher's open access policy
ISSN 0425-1644
Publication date 2017-05-22
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/evj.12703
Open Access Status Not yet assessed
Volume 49
Issue 5
Start page 570
End page 576
Total pages 35
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Subject 3402 Equine
Abstract Insulin dysregulation is the hallmark of Equine Metabolic Syndrome and has received attention because of its direct association with laminitis. In the absence of an adequate treatment for laminitis, a focus on prophylaxis is needed, making early detection of individuals at risk of developing laminitis one of the main challenges in equine endocrinology. Recent studies have shown that insulin dysregulation goes beyond tissue insulin resistance and it is now demonstrated that the equine enteroinsular axis plays a major role in insulin secretion and equine hyperinsulinaemia. In this review, we discuss the different tests currently available to diagnose insulin dysregulation in horses: the ones investigating tissue insulin resistance and the ones investigating the enteroinsular axis, detailing their goals, practicalities and limitations. This review supports the contention that the diagnosis of equine insulin dysregulation should now be based on the investigation of both tissue insulin resistance and the equine enteroinsular axis. Regardless of the tests used many factors of variation, such as breed, diet, fasting state or season, have been identified and could potentially confound the results of a specific test. Therefore, careful interpretation of the results of a given test in each individual situation is required to optimise the detection of horses at risk of laminitis.
Keyword Horse
Insulin dysregulation
Insulin resistence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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Created: Fri, 02 Jun 2017, 11:31:57 EST by Francois-rene Bertin on behalf of School of Veterinary Science