Molecular clocks in reptiles: Life history influences rate of molecular evolution

Bromham, Lindell (2002) Molecular clocks in reptiles: Life history influences rate of molecular evolution. Molecular Biology And Evolution, 19 3: 302-309. doi:10.1093/oxfordjournals.molbev.a004083

Author Bromham, Lindell
Title Molecular clocks in reptiles: Life history influences rate of molecular evolution
Journal name Molecular Biology And Evolution   Check publisher's open access policy
ISSN 0737-4038
Publication date 2002-03-01
Sub-type Article (original research)
DOI 10.1093/oxfordjournals.molbev.a004083
Open Access Status Not yet assessed
Volume 19
Issue 3
Start page 302
End page 309
Total pages 8
Place of publication Lawrence, KS, USA
Publisher Society for Molecular Biology and Evolution
Language eng
Subject C1
270208 Molecular Evolution
780105 Biological sciences
Abstract Life history has been implicated as a determinant of variation in rate of molecular evolution amongst vertebrate species because of a negative correlation between bode size and substitution rate for many Molecular data sets. Both the generality and the cause of the negative bode size trend have been debated, and the validity of key studies has been questioned (particularly concerning the failure to account for phylogenetic bias). In this study, a comparative method has been used to test for an association between a range of life-history variables-such as body size age at maturity, and clutch size-and DNA substitution rate for three genes (NADH4, cytochrome b, and c-mos). A negative relationship between body size and rate of molecular evolution was found for phylogenetically independent pairs of reptile species spanning turtles. lizards. snakes, crocodile, and tuatara. Although this Study was limited by the number of comparisons for which both sequence and lite-history data were available, the results, suggest that a negative bode size trend in rate of molecular evloution may be a general feature of reptile molecular evolution. consistent with similar studies of mammals and birds. This observation has important implications for uncovering the mechanisms of molecular evolution and warns against assuming that related lineages will share the same substitution rate (a local molecular clock) in order to date evolutionary divergences from DNA sequences.
Keyword Biochemistry & Molecular Biology
Evolutionary Biology
Genetics & Heredity
Molecular Clock
Molecular Evolution
Generation Time Effect
Substitution Rate
Relative Rates
Comparative Method
Dna-sequence Evolution
Male-driven Evolution
Relative-rate Test
Nucleotide Substitution
Correlated Rates
Nuclear Genes
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 69 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 03:11:47 EST