'Omic' approaches to study Uropathogenic Escherichia coli virulence

Lo, Alvin W., Moriel, Danilo G., Phan, Minh-Duy, Schulz, Benjamin L., Kidd, Timothy J., Beatson, Scott A. and Schembri, Mark A. (2017) 'Omic' approaches to study Uropathogenic Escherichia coli virulence. Trends in Microbiology, 25 9: 729-740. doi:10.1016/j.tim.2017.04.006

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Author Lo, Alvin W.
Moriel, Danilo G.
Phan, Minh-Duy
Schulz, Benjamin L.
Kidd, Timothy J.
Beatson, Scott A.
Schembri, Mark A.
Title 'Omic' approaches to study Uropathogenic Escherichia coli virulence
Formatted title
'Omic' approaches to study Uropathogenic Escherichia coli virulence
Journal name Trends in Microbiology   Check publisher's open access policy
ISSN 0966-842X
1878-4380
Publication date 2017-05-24
Year available 2017
Sub-type Article (original research)
DOI 10.1016/j.tim.2017.04.006
Open Access Status Not yet assessed
Volume 25
Issue 9
Start page 729
End page 740
Total pages 12
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple 'omic' technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.
Formatted abstract
Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple ‘omic’ technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.
Keyword UPEC
genomics
metabolomics
proteomics
transcriptomics
virulence
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 02 Jun 2017, 08:59:02 EST by Timothy Kidd on behalf of School of Chemistry & Molecular Biosciences