Mast cell/T cell interactions in oral lichen planus

Zhao, Z. Z., Savage, N. W., Sugerman, P. B. and Walsh, L. J. (2002) Mast cell/T cell interactions in oral lichen planus. Journal of Oral Pathology & Medicine, 31 4: 189-195. doi:10.1034/j.1600-0714.2002.310401.x

Author Zhao, Z. Z.
Savage, N. W.
Sugerman, P. B.
Walsh, L. J.
Title Mast cell/T cell interactions in oral lichen planus
Journal name Journal of Oral Pathology & Medicine   Check publisher's open access policy
ISSN 0904-2512
Publication date 2002-01-01
Year available 2002
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1034/j.1600-0714.2002.310401.x
Open Access Status Not yet assessed
Volume 31
Issue 4
Start page 189
End page 195
Total pages 7
Editor E Dabelsteen
Place of publication Denmark
Publisher Munksgaard Int
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Lichen planus is a disorder characterized by lesions of the skin and oral mucous membranes. Although many patients have involvement of both skin and oral mucosa at some stage during the progress of the disease, a larger group has oral involvement alone. It has been reported that oral lichen planus (OLP) affects one to two percent of the general population and has the potential for malignant transformation in some cases (1, 2). Like many chronic inflammatory skin diseases, it often persists for many years. Numerous disorders may be associated with OLP such as graft-vs.-host disease and Hepatitis C virus infection (3), however, it is unclear how such diverse influences elicit the disease and indeed whether they are identical to idiopathic OLP Available evidence supports the view that OLP is a cell-mediated immunological response to an induced antigenic change in the mucosa (4-6). Studies of the immunopathogenesis of OLP aim to provide specific novel treatments as well as contributing to our understanding of other cell-mediated inflammatory diseases. In this paper, the interactions between mast cells and T cells are explored from the standpoint of immune regulation. From these data, a unifying hypothesis for the immunopathogenesis of OLP is then developed and presented.
Keyword Dentistry, Oral Surgery & Medicine
Mast Cell
Line Hmc-1
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Dentistry Publications
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Citation counts: TR Web of Science Citation Count  Cited 47 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 03:09:26 EST