New developments in dry powder pulmonary vaccine delivery

Sou, Tomas, Meeusen, Els N., de Veer, Michael, Morton, David A. V., Kaminskas, Lisa M. and McIntosh, Michelle P. (2011) New developments in dry powder pulmonary vaccine delivery. Trends in Biotechnology, 29 4: 191-198. doi:10.1016/j.tibtech.2010.12.009

Author Sou, Tomas
Meeusen, Els N.
de Veer, Michael
Morton, David A. V.
Kaminskas, Lisa M.
McIntosh, Michelle P.
Title New developments in dry powder pulmonary vaccine delivery
Journal name Trends in Biotechnology   Check publisher's open access policy
ISSN 0167-7799
Publication date 2011-04-01
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tibtech.2010.12.009
Open Access Status Not yet assessed
Volume 29
Issue 4
Start page 191
End page 198
Total pages 8
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery.
Keyword Biotechnology & Applied Microbiology
Biotechnology & Applied Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 55 times in Scopus Article | Citations
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