Targeting the lymphatics using dendritic polymers (dendrimers)

Kaminskas, Lisa M. and Porter, Christopher J. H. (2011) Targeting the lymphatics using dendritic polymers (dendrimers). Advanced Drug Delivery Reviews, 63 10-11: 890-900. doi:10.1016/j.addr.2011.05.016

Author Kaminskas, Lisa M.
Porter, Christopher J. H.
Title Targeting the lymphatics using dendritic polymers (dendrimers)
Journal name Advanced Drug Delivery Reviews   Check publisher's open access policy
ISSN 0169-409X
Publication date 2011-09-10
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.addr.2011.05.016
Open Access Status Not yet assessed
Volume 63
Issue 10-11
Start page 890
End page 900
Total pages 11
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Dendrimers are unique biomaterials that are constructed by the stepwise addition of layers (generations) of polymer around a central core. They can be constructed with a range of molecular weights and have a polyfunctional surface that facilitates the attachment of drugs and pharmacokinetic modifiers such PEG or targeting moieties. These properties have led to considerable interest in the development of dendrimers for a range of biomedical applications. After subcutaneous administration, larger dendrimers in particular (> 8 nm), preferentially drain from the injection site into the peripheral lymphatic capillaries and therefore have potential as lymphatic imaging agents for magnetic resonance and optical fluorescence lymphangiography and as vectors for drug-targeting to lymphatic sites of disease progression. In general, lymphatic targeting of dendrimers is enhanced by increasing size although ultimately larger constructs may be incompletely absorbed from the injection site. Increasing hydrophilicity and reducing surface charge enhances drainage from subcutaneous injection sites, but the reverse is true of uptake into lymph nodes where charge and hydrophobicity promote retention. Larger hydrophilic dendrimers are also capable of extravasation from the systemic circulation, absorption into the lymphatic system and recirculation into the blood. Lymphatic recirculation may therefore be a characteristic of PEGylated dendrimers with long systemic circulation times.
Keyword Bioavailability
Drug delivery
Lymphatic transport
Magnetic resonance imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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