Relationship of XIST expression and responses of ovarian cancer to chemotherapy

Huang, KC, Rao, PH, Lau, CC, Heard, E, Ng, SK, Brown, C, Mok, SC, Berkowitz, RS and Ng, SW (2002) Relationship of XIST expression and responses of ovarian cancer to chemotherapy. Molecular Cancer Therapeutics, 1 10: 769-776.

Author Huang, KC
Rao, PH
Lau, CC
Heard, E
Ng, SK
Brown, C
Mok, SC
Berkowitz, RS
Ng, SW
Title Relationship of XIST expression and responses of ovarian cancer to chemotherapy
Journal name Molecular Cancer Therapeutics   Check publisher's open access policy
ISSN 1535-7163
Publication date 2002-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 1
Issue 10
Start page 769
End page 776
Total pages 8
Editor D.D. Von Hoff
Place of publication United States
Publisher American Association for Cancer Research
Language eng
Subject C1
270201 Gene Expression
730108 Cancer and related disorders
Abstract Expression profiling to characterize cancer pharmacology has become a new approach to discover novel molecular targets for prognostic markers and cancer therapy. In a study to compare the global RNA expression profiles between primary and recurrent ovarian tumors from the same patient, we have identified XIST (inactive X chromosome-specific transcripts) as the most differentially expressed gene that was down-regulated in the recurrent tumor. XIST encodes a spliced noncoding polyadenylated transcript that is unique in being expressed exclusively from the inactive X chromosome and is involved in the X-inactivation process. Subsequent characterization of XIST expression in a panel of female cancer cell lines showed that the expression level of XIST correlates significantly with Taxol sensitivity. The clinical relevance of this observation is demonstrated by the strong association between XIST RNA levels and disease-free periods of ovarian cancer patients in a group of 21 ovarian cancer cases with Taxol in the therapeutic regiments. Cytogenetic studies on ovarian cancer cell lines indicated that loss of inactive X chromosome is one mechanism for the loss of XIST transcripts in the cell lines. Our data suggest that XIST expression may be a potential marker for chemotherapeutic responses in ovarian cancer.
Keyword Oncology
X-chromosome Inactivation
Q-Index Code C1
Grant ID CA70216
GM 59920
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Physical Sciences Publications
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Created: Wed, 15 Aug 2007, 03:03:36 EST