Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension

Wanstall, J. C., Gambino, A., Jeffery, T. K., Cahill, M. M., Bellomo, D., Hayward, N. K. and Kay, G. F. (2002) Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension. Cardiovascular Research, 55 2: 361-368. doi:10.1016/S0008-6363(02)00440-6


Author Wanstall, J. C.
Gambino, A.
Jeffery, T. K.
Cahill, M. M.
Bellomo, D.
Hayward, N. K.
Kay, G. F.
Title Vascular endothelial growth factor-B-deficient mice show impaired development of hypoxic pulmonary hypertension
Journal name Cardiovascular Research   Check publisher's open access policy
ISSN 0008-6363
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1016/S0008-6363(02)00440-6
Open Access Status Not yet assessed
Volume 55
Issue 2
Start page 361
End page 368
Total pages 8
Editor J.P. Harris
Place of publication Netherlands
Publisher Elsevier Science
Language eng
Subject C1
321003 Cardiology (incl. Cardiovascular Diseases)
730106 Cardiovascular system and diseases
1102 Cardiovascular Medicine and Haematology
Abstract To test the hypothesis that Vegf-B contributes to the pulmonary vascular remodelling, and the associated pulmonary hypertension, induced by exposure of mice to chronic hypoxia. Methods: Right ventricular systolic pressure, the ratio of right ventricle/[left ventricle+septum] (RV/[LV+S]) and the thickness of the media (relative to vessel diameter) of intralobar pulmonary arteries (o.d. 50-150 and 151-420 mum) were determined in Vegfb knockout mice (Vegfb(-/-); n=17) and corresponding wild-type mice (Vegfb(+/+); n=17) exposed to chronic hypoxia (10% oxygen) or housed in room air (normoxia) for 4 weeks. Results: In Vegfb(+/+) mice hypoxia caused (i) pulmonary hypertension (a 70% increase in right ventricular systolic pressure compared with normoxic Vegfb(+/+) mice; P<0.001), (ii) right ventricular hypertrophy (a 66% increase in RV/[LV+S]; P<0.001) and (iii) pulmonary vascular remodelling (a 27-36% increase in pulmonary arterial medial thickness; P<0.05). In contrast, in-Vegfb(-/-) mice hypoxia did not cause any increase in either right ventricular systolic pressure or pulmonary arterial medial thickness; also right ventricular hypertrophy (41% increase in RV/[LV+S]; P<0.001) was less pronounced (P<0.05) than in Vegfb(+/+) mice. Conclusion: Vegf-B may have a role in the development of chronic hypoxic pulmonary hypertension. in mice by contributing to pulmonary vascular remodelling. If so, the effect of Vegf-B appears to be different from that of Vegf-A which is reported to protect against, rather than contribute to, hypoxia-induced pulmonary vascular remodelling. (C) 2002 Elsevier Science B.V. All rights reserved.
Keyword Cardiac & Cardiovascular Systems
Growth Factors
Hypertrophy
Hypoxia
Pulmonary Circulation
Remodelling
Smooth-muscle Cells
Vegf-b
Extracellular-matrix
Mitogenic Activity
Nitric-oxide
Rats
Expression
Artery
Gene
Metalloproteinases
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 03:00:53 EST