Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: A randomized, double-blind, prospective trial

Gordon Macleod, A. W., Ashford, B., Voltz, M., Williams, B., Cramond, T. R., Gorta, L. and Simpson, J. M. (2002) Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: A randomized, double-blind, prospective trial. Australian Dental Journal, 47 2: 147-151. doi:10.1111/j.1834-7819.2002.tb00319.x


Author Gordon Macleod, A. W.
Ashford, B.
Voltz, M.
Williams, B.
Cramond, T. R.
Gorta, L.
Simpson, J. M.
Title Paracetamol versus paracetamol-codeine in the treatment of post-operative dental pain: A randomized, double-blind, prospective trial
Journal name Australian Dental Journal   Check publisher's open access policy
ISSN 0045-0421
Publication date 2002-01-01
Sub-type Article (original research)
DOI 10.1111/j.1834-7819.2002.tb00319.x
Open Access Status Not yet assessed
Volume 47
Issue 2
Start page 147
End page 151
Total pages 5
Place of publication Sydney
Publisher Australian Dental Association Inc
Language eng
Subject C1
320899 Dentistry not elsewhere classified
730112 Oro-dental and disorders
Abstract Background: Codeine is frequently added to paracetamol to treat post-operative dento-alveolar pain; studies have shown effectiveness in relief of post-operative pain at high doses but at the expense of central nervous and gastrointestinal side effects. There has been no trial to compare the efficacy and safety of paracetamol 1000mg with paracetamol 1000mg combined with codeine 30mg. Method. A randomized, single centre, double-blind prospective parallel group trial was performed to compare paracetamol 1000mg with paracetamol 1000mg with codeine 30mg for the relief of pain following surgical removal of impacted third molars, and analysed on an intention-to-treat (ITT) basis. Eighty-two patients were assigned randomly to receive either drug for a maximum of three doses. Patients recorded their pain intensity one hour after surgery and hourly thereafter for 12 hours. Results: The average increase in pain intensity over 12 hours was significantly less in patients receiving paracetamol plus codeine than in those receiving paracetamol alone (p=0.03) -1.81cm/h compared with 0.45cm/h - a difference of 1.13cm/h (95 per cent Cl: 0.18 to 2.08). Of the patients who received the paracetamol codeine combination, 62 per cent used escape medication compared with 75 per cent of those on paracetamol alone (p=0.20). There was no significant difference between the two groups in the proportion of patients experiencing adverse events (P=0.5). Conclusion: A combination of 1000mg paracetamol and 30mg codeine was significantly more effective in controlling pain for 12 hours following third molar removal, with no significant difference of side effects during the 12 hour period studied.
Keyword Dentistry, Oral Surgery & Medicine
Codeine
Combination Analgesics
Paracetamol
Post-operative Pain
Third Molar Removal
Visual Analog Scale
Analgesic Efficacy
Moderate Pain
Acetaminophen
Combination
Diflunisal
Ibuprofen
Removal
Relief
Single
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Dentistry Publications
 
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Created: Wed, 15 Aug 2007, 03:00:26 EST