Mouse Sox8 is located between, not within, the t-complex deletions t(w18) and t(h20) on chromosome 17

Schepers, G. and Koopman, P. (2001) Mouse Sox8 is located between, not within, the t-complex deletions t(w18) and t(h20) on chromosome 17. Cytogenetics And Cell Genetics, 93 1-2: 91-93. doi:10.1159/000056956


Author Schepers, G.
Koopman, P.
Title Mouse Sox8 is located between, not within, the t-complex deletions t(w18) and t(h20) on chromosome 17
Journal name Cytogenetics And Cell Genetics   Check publisher's open access policy
ISSN 0301-0171
Publication date 2001-01-01
Year available 2001
Sub-type Article (original research)
DOI 10.1159/000056956
Open Access Status Not yet assessed
Volume 93
Issue 1-2
Start page 91
End page 93
Total pages 3
Editor H P Klinger
M Schmid
Place of publication Basel
Publisher Karger
Language eng
Subject C1
Abstract The SOX family of developmental transcription factors is known to play critical roles in cell lineage specification, fate determination and differentiation during development in diverse phyla. Their importance is underscored by their involvement in a number of human diseases and mouse mutants, and by targeted mutation in mice. SOX8 is broadly expressed during development and is located on human chromosome 16p and within the t-complex on mouse chromosome 17, in the vicinity of two mutations t(w18) and t(h20). Here we analyse mutant genomic DNA to show that the Sox8 gene locus lies outside the deletion regions of both t(w18) and t(h20) and between these deletions. These data exclude Sox8 from contributing to the t(w18) and t(h20) phenotypes, and provide an additional marker for structural characterization of this complex genomic region. Copyright (C) 2001 S. Karger AG, Basel.
Keyword Cell Biology
Genetics & Heredity
Mutations
Family
Maps
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 02:59:23 EST