Sox18 expression in blood vessels and feather buds during chicken embryogenesis

Olsson, J. E., Kamachi, Y., Penning, S., Muscat, G. E. O., Kondoh, H. and Koopman, P. (2001) Sox18 expression in blood vessels and feather buds during chicken embryogenesis. Gene, 271 2: 151-158. doi:10.1016/S0378-1119(01)00505-4


Author Olsson, J. E.
Kamachi, Y.
Penning, S.
Muscat, G. E. O.
Kondoh, H.
Koopman, P.
Title Sox18 expression in blood vessels and feather buds during chicken embryogenesis
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1016/S0378-1119(01)00505-4
Volume 271
Issue 2
Start page 151
End page 158
Total pages 8
Editor G Bernardina
Place of publication Netherlands
Publisher Elsevier Science B.V.
Collection year 2001
Language eng
Subject C1
Abstract Sox18 encodes a transcription factor known to be important for the development of blood vessels and hair follicles in mice. In order to study the functional conservation of this gene through evolution, we have isolated and characterized Sox18 in chickens. cSox18 shows a high degree of sequence homology to both the mouse and human orthologues, particularly in the high mobility group DNA-binding domain and to a lesser extent in the transcriptional activation domain. A region of unusually high sequence conservation at the C-terminus may represent a further, previously unrecognized functional domain. Both the chicken and human proteins appear to be truncated at the N-terminus relative to mouse SOX18. In situ hybridization analyses showed expression in the developing vasculature and feather follicles, consistent with reported expression in the mouse embryo. In addition, cSox18 mRNA was observed in the retina and claw beds. (C) 2001 Elsevier Science B.V. All rights reserved.
Keyword Genetics & Heredity
Sox Genes
Angiogenesis
Vasculogenesis
Transcription Factors
Organogenesis
In Situ Hybridization
Autosomal Sex Reversal
Sry-related Gene
Campomelic Dysplasia
Transcription Factor
Cdna Cloning
Xy Females
Mutations
Sequence
Model
Mice
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Wed, 15 Aug 2007, 02:59:09 EST