Endothelial progenitors: a consensus statement on nomenclature

Medina, Reinhold J., Barber, Chad L., Sabatier, Florence, Dignat-George, Francoise, Melero-Martin, Juan M., Khosrotehrani, Kiarash, Ohneda, Osamu, Randi, Anna M., Chan, Jerry K. Y., Yamaguchi, Teruhide, Van Hinsbergh, Victor W. M., Yoder, Mervin C. and Stitt, Alan W. (2017) Endothelial progenitors: a consensus statement on nomenclature. Stem Cells Translational Medicine, 6 5: 1316-1320. doi:10.1002/sctm.16-0360

Author Medina, Reinhold J.
Barber, Chad L.
Sabatier, Florence
Dignat-George, Francoise
Melero-Martin, Juan M.
Khosrotehrani, Kiarash
Ohneda, Osamu
Randi, Anna M.
Chan, Jerry K. Y.
Yamaguchi, Teruhide
Van Hinsbergh, Victor W. M.
Yoder, Mervin C.
Stitt, Alan W.
Title Endothelial progenitors: a consensus statement on nomenclature
Journal name Stem Cells Translational Medicine   Check publisher's open access policy
ISSN 2157-6564
Publication date 2017-05-01
Year available 2017
Sub-type Article (original research)
DOI 10.1002/sctm.16-0360
Open Access Status DOI
Volume 6
Issue 5
Start page 1316
End page 1320
Total pages 5
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Language eng
Subject 1309 Developmental Biology
1307 Cell Biology
Abstract Endothelial progenitor cell (EPC) nomenclature remains ambiguous and there is a general lack of concordance in the stem cell field with many distinct cell subtypes continually grouped under the term “EPC.” It would be highly advantageous to agree on standards to confirm an endothelial progenitor phenotype and this should include detailed immunophenotyping, potency assays, and clear separation from hematopoietic angiogenic cells which are not endothelial progenitors. In this review, we seek to discourage the indiscriminate use of “EPCs,” and instead propose precise terminology based on defining cellular phenotype and function. Endothelial colony forming cells and myeloid angiogenic cells are examples of two distinct and well-defined cell types that have been considered EPCs because they both promote vascular repair, albeit by completely different mechanisms of action. It is acknowledged that scientific nomenclature should be a dynamic process driven by technological and conceptual advances; ergo the ongoing “EPC” nomenclature ought not to be permanent and should become more precise in the light of strong scientific evidence. This is especially important as these cells become recognized for their role in vascular repair in health and disease and, in some cases, progress toward use in cell therapy.
Keyword Angiogenesis
Cellular therapy
Endothelial cell
Progenitor cells
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DK106846
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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