Lexical ambiguity resolution during sentence processing in Parkinson's disease: an event-related potential study

Angwin, Anthony J., Dissanayaka, Nadeeka N. W., McMahon, Katie L., Silburn, Peter A. and Copland, David A. (2017) Lexical ambiguity resolution during sentence processing in Parkinson's disease: an event-related potential study. PLoS One, 12 5: e0176281-e0176281. doi:10.1371/journal.pone.0176281


Author Angwin, Anthony J.
Dissanayaka, Nadeeka N. W.
McMahon, Katie L.
Silburn, Peter A.
Copland, David A.
Title Lexical ambiguity resolution during sentence processing in Parkinson's disease: an event-related potential study
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2017-05-05
Year available 2017
Sub-type Article (original research)
DOI 10.1371/journal.pone.0176281
Open Access Status DOI
Volume 12
Issue 5
Start page e0176281
End page e0176281
Total pages 14
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract Event-related potentials (ERPs) were recorded to investigate lexical ambiguity resolution during sentence processing in 16 people with Parkinson's disease (PD) and 16 healthy controls. Sentences were presented word-by-word on computer screen, and participants were required to decide if a subsequent target word was related to the meaning of the sentence. The task consisted of related, unrelated and ambiguous trials. For the ambiguous trials, the sentence ended with an ambiguous word and the target was related to one of the meanings of that word, but not the one captured by the sentence context (e.g., He dug with the spade', Target 'ACE'). Both groups demonstrated slower reaction times and lower accuracy for the ambiguous condition relative to the unrelated condition, however accuracy was impacted by the ambiguous condition to a larger extent in the PD group. These results suggested that PD patients experience increased difficulties with contextual ambiguity resolution. The ERP results did not reflect increased ambiguity resolution difficulties in PD, as a similar N400 effect was evident for the unrelated and ambiguous condition in both groups. However, the magnitude of the N400 for these conditions was correlated with a measure of inhibition in the PD group, but not the control group. The ERP results suggest that semantic processing may be more compromised in PD patients with increased response inhibition deficits.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Grant ID DP120104420
Institutional Status UQ

 
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