Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran

Shang, Zhuo, Salim, Angela A. and Capon, Robert J. (2017) Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran. Journal of Natural Products, 80 4: 1167-1172. doi:10.1021/acs.jnatprod.7b00144


Author Shang, Zhuo
Salim, Angela A.
Capon, Robert J.
Title Chaunopyran A: co-cultivation of marine mollusk-derived fungi activates a rare class of 2-alkenyl-tetrahydropyran
Journal name Journal of Natural Products   Check publisher's open access policy
ISSN 1520-6025
0163-3864
Publication date 2017-04-28
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.jnatprod.7b00144
Open Access Status Not yet assessed
Volume 80
Issue 4
Start page 1167
End page 1172
Total pages 6
Place of publication Washington, DC United States
Publisher American Chemical Society
Language eng
Subject 1602 Analytical Chemistry
1313 Molecular Medicine
3004 Pharmacology
3003 Pharmaceutical Science
3002 Drug Discovery
2707 Complementary and alternative medicine
1605 Organic Chemistry
Abstract Co-cultivation of Chaunopycnis sp. (CMB-MF028) and Trichoderma hamatum (CMB-MF030), fungal strains co-isolated from the inner tissue of an intertidal rock platform mollusc (Siphonaria sp), resulted in transcriptional activation of a rare class of 2-alkenyl-tetrahydropyran, chaunopyran A (7), and biotransformation and deactivation of the antifungal pyridoxatin (1), to methyl-pyridoxatin (8). This study illustrates the complexity of offensive and counter-offensive molecular defenses encountered during fungal co-cultivation, and the opportunities for activating new, otherwise transcriptionally silent secondary metabolites.
Formatted abstract
Co-cultivation of Chaunopycnis sp. (CMB-MF028) and Trichoderma hamatum (CMB-MF030), fungal strains co-isolated from the inner tissue of an intertidal rock platform mollusc (Siphonaria sp), resulted in transcriptional activation of a rare class of 2-alkenyl-tetrahydropyran, chaunopyran A (7), and biotransformation and deactivation of the antifungal pyridoxatin (1), to methyl-pyridoxatin (8). This study illustrates the complexity of offensive and counter-offensive molecular defenses encountered during fungal co-cultivation, and the opportunities for activating new, otherwise transcriptionally silent secondary metabolites.
Keyword Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Plant Sciences
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP120100183
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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Created: Mon, 29 May 2017, 01:00:46 EST by Web Cron on behalf of Institute for Molecular Bioscience