Child-Pugh class, nutritional indicators and early liver transplant outcomes

Abbott, W. J., Thomson, A., Steadman, C., Gatton, M. L., Bothwell, C., Kerlin, P., Wall, D. R. and Lynch, S. V, (2001) Child-Pugh class, nutritional indicators and early liver transplant outcomes. Hepato-gastroenterology, 48 39: 823-827.

Author Abbott, W. J.
Thomson, A.
Steadman, C.
Gatton, M. L.
Bothwell, C.
Kerlin, P.
Wall, D. R.
Lynch, S. V,
Title Child-Pugh class, nutritional indicators and early liver transplant outcomes
Journal name Hepato-gastroenterology   Check publisher's open access policy
ISSN 0172-6390
Publication date 2001-01-01
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 48
Issue 39
Start page 823
End page 827
Total pages 5
Editor N.J. Lygidakis
Place of publication Greece
Publisher Hepato-Gastroenterology
Language eng
Subject C1
321029 Surgery
730109 Surgical methods and procedures
Abstract Background/Aims: Patients with chronic liver disease undergoing liver transplantation have reduced body fat and muscle mass. The extent to which nutritional indicators and Child-Pugh class are predictive of postoperative outcome in adults is unclear. The aims of this study were to determine in adult patients undergoing transplant 1) the influence of preoperative Child-Pugh class and nutritional indicators on early transplant outcomes and one-year survival, 2) the relationship between nutritional indicators and Child-Pugh class and disease type. This study included 80 patients (1990-1994). Methodology: The nutritional indicators utilized were grip strength, triceps skinfold thickness and uncorrected mid-arm muscle area. Measured outcomes were ventilator time, intensive care stay, postoperative hospital stay and one-year survival. Results: Early morbidity was determined in survivors. Child-Pugh class C patients required longer ventilation and spent more time in the intensive care unit than Child-Pugh classes A and B. No significant relationships were found length of hospital stay. Relationships between the nutritional indicators (when controlled for Child-Pugh class) and early morbidity could not be determined due;to insufficient data. No relationship was established between one-year survival and Child-Pugh class or the nutritional indicators. Grip strength and mid-arm muscle area were lower in the patients in Child-Pugh:classes B and C. Parenchymal liver disease was associated with lower grip strength and mid-arm muscle area when compared to cholestatic disease. Conclusions: Child-Pugh class C is associated with greater early postoperative morbidity. Advanced Child-Pugh class is also associated with diminished muscle status and parenchymal disease.
Keyword Gastroenterology & Hepatology
Nutritional Indicators
Liver Transplant
Grip Strength
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 02:43:32 EST