The central nucleus of the amygdala: a conduit for modulation of HPA axis responses to an immune challenge?

Buller, K. M., Crane, J. and Day, T. A. (2001) The central nucleus of the amygdala: a conduit for modulation of HPA axis responses to an immune challenge?. Stress: the international journal on the biology of stress, 4 4: 277-287. doi:10.3109/10253890109014752


Author Buller, K. M.
Crane, J.
Day, T. A.
Title The central nucleus of the amygdala: a conduit for modulation of HPA axis responses to an immune challenge?
Journal name Stress: the international journal on the biology of stress   Check publisher's open access policy
ISSN 1025-3890
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.3109/10253890109014752
Open Access Status Not yet assessed
Volume 4
Issue 4
Start page 277
End page 287
Total pages 11
Editor E Ronald de Kloet
richard McCarty
JA Russell
Place of publication Switzerland
Publisher Gordon and Breach - Harwood Academic
Language eng
Subject C1
320700 Neurosciences
730104 Nervous system and disorders
Abstract Physical stressors such as infection, inflammation and tissue injury elicit activation of the hypothalamic-pituitary-adrenal (HPA) axis. This response has significant implications for both immune and central nervous system function. Investigations in rats into the neural substrates responsible for HPA axis activation to an immune challenge have predominantly utilized an experimental paradigm involving the acute administration of the pro-inflammatory cytokine interleukin-1β (IL-1β). It is well recognized that medial parvocellular corticotrophin-releasing factor cells of the paraventricular nucleus (mPVN CRF) are critical in generating HPA axis responses to an immune challenge but little is known about how peripheral immune signals can activate and/or modulate the mPVN CRF cells. Studies that have examined the afferent control of the mPVN CRF cell response to systemic IL-1β have centred largely on the inputs from brainstem catecholamine cells. However, other regulatory neuronal populations also merit attention and one such region is a component of the limbic system, the central nucleus of the amygdala (CeA). A large number of CeA cells are recruited following systemic IL-1β administration and there is a significant body of work indicating that the CeA can influence HPA axis function. However, the contribution of the CeA to HPA axis responses to an immune challenge is only just beginning to be addressed. This review examines three aspects of HPA axis control by systemic IL-1β: (i) Whether the CeA has a role in generating HPA axis responses to systemic IL-1β, (ii) the identity of the neural connections between the CeA and mPVN CRF cells that might be important to HPA axis responses and (iii) the mechanisms by which systemic IL-1β triggers the recruitment of CeA cells.
Keyword Bed nucleus of the stria terminalis
Central amygdala
HPA axis
Interleukin-1β
Neuroimmune interactions
Nucleus tractus solitarius
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 02:42:03 EST