Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications

Maity, Dipak, Chandrasekharan, Prashant, Pradhan, Pallab, Chuang, Kai-Hsiang, Xue, Jun-Min, Feng, Si-Shen and Ding, Jun (2011) Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications. Journal of Materials Chemistry, 21 38: 14717-14724. doi:10.1039/c1jm11982f

Author Maity, Dipak
Chandrasekharan, Prashant
Pradhan, Pallab
Chuang, Kai-Hsiang
Xue, Jun-Min
Feng, Si-Shen
Ding, Jun
Title Novel synthesis of superparamagnetic magnetite nanoclusters for biomedical applications
Journal name Journal of Materials Chemistry   Check publisher's open access policy
ISSN 1364-5501
Publication date 2011-10-01
Year available 2011
Sub-type Article (original research)
DOI 10.1039/c1jm11982f
Open Access Status Not yet assessed
Volume 21
Issue 38
Start page 14717
End page 14724
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Language eng
Abstract In this work, we report a novel method of single step facile synthesis of magnetite nanoclusters via thermal decomposition of iron(III) acetylacetonate in a liquid mixture of tri(ethylene glycol) (TREG) and triethanolamine (TREA). The optimized ratio of TREG : TREA has been found to be 1 : 4 (v/v) for the formation of well dispersed MNC-14 magnetite nanoclusters with high M-s values (75 emu g(-1)) as compared to MNC-10 magnetite nanoparticles (63 emu g(-1)). The MNC-14 nanoclusters were found to be nontoxic to MCF-7 cells up to an iron concentration of 10 mg ml(-1). The MNC-14 nanoclusters yielded high specific absorption rate (SAR) values (similar to 500 Watt g(-1) at 89 kA m(-1) AC magnetic field and 240 kHz frequency) and thus qualified for their possible use in magnetic hyperthermia treatment, while MNC-10 nanoparticles possess a much lower SAR value of 135 Watt g(-1). In vitro magnetic hyperthermia experiments (using the MNC-14 nanoclusters with the iron concentration of 0.5 mg ml(-1)) showed about 74% loss in viability of MCF-7 breast cancer cells indicating that they are a very suitable candidate for magnetic hyperthermia treatment of cancer. The r2 and r2(*) relaxivity values of MNC-14 nanoclusters (294.99 and 450.05 s(-1) mM(-1)) as measured by a 9.4 T MRI scanner were higher than those for the MNC-10 nanoparticles (205.6 and 309.2 s(-1) mM(-1)). The MNC-14 nanoclusters also showed very promising in vivo tumor imaging. Thus, the newly synthesized novel MNC-14 nanoclusters possess great potential in clinical MRI and magnetic hyperthermia applications and may be used simultaneously for cancer diagnosis and therapy.
Keyword Chemistry, Physical
Materials Science, Multidisciplinary
Materials Science
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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