Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena, Muller, David C., Lagiou, Pagona, Ahrens, Wolfgang, Holcatova, Ivana, Merletti, Franco, Kjaerheim, Kristina, Polesel, Jerry, Simonato, Lorenzo, Canova, Cristina, Castellsague, Xavier, Macfarlane, Tatiana V., Znaor, Ariana, Thomson, Peter, Robinson, Max, Conway, David I., Healy, Claire M., Tjonneland, Anne, Westin, Ulla, Ekstrom, Johanna, Chang-Claude, Jenny, Kaaks, Rudolf, Overvad, Kim, Drogan, Dagmar, Hallmans, Goran, Laurell, Goran, Bueno-de-Mesquita, H. B., Peeters, Petra H., Agudo, Antonio, Larranaga, Nerea, Travis, Ruth C., Palli, Domenico, Barricarte, Aurelio, Trichopoulou, Antonia, George, Saitakis, Trichopoulos, Dimitrios, Ramon Quiros, J., Grioni, Sara, Sacerdote, Carlotta, Navarro, Carmen, Sanchez, Maria-Jose, Tumino, Rosario, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Clavel-Chapelon, Francoise, Panico, Salvatore, Weiderpass, Elisabete, Lund, Eiliv, Gram, Inger T., Riboli, Elio, Pawlita, Michael, Waterboer, Tim, Kreimer, Aimee R., Johansson, Mattias and Brennan, Paul (2016) Combined effects of smoking and HPV16 in oropharyngeal cancer. International Journal of Epidemiology, 45 3: 752-761. doi:10.1093/ije/dyw069


Author Anantharaman, Devasena
Muller, David C.
Lagiou, Pagona
Ahrens, Wolfgang
Holcatova, Ivana
Merletti, Franco
Kjaerheim, Kristina
Polesel, Jerry
Simonato, Lorenzo
Canova, Cristina
Castellsague, Xavier
Macfarlane, Tatiana V.
Znaor, Ariana
Thomson, Peter
Robinson, Max
Conway, David I.
Healy, Claire M.
Tjonneland, Anne
Westin, Ulla
Ekstrom, Johanna
Chang-Claude, Jenny
Kaaks, Rudolf
Overvad, Kim
Drogan, Dagmar
Hallmans, Goran
Laurell, Goran
Bueno-de-Mesquita, H. B.
Peeters, Petra H.
Agudo, Antonio
Larranaga, Nerea
Travis, Ruth C.
Palli, Domenico
Barricarte, Aurelio
Trichopoulou, Antonia
George, Saitakis
Trichopoulos, Dimitrios
Ramon Quiros, J.
Grioni, Sara
Sacerdote, Carlotta
Navarro, Carmen
Sanchez, Maria-Jose
Tumino, Rosario
Severi, Gianluca
Boutron-Ruault, Marie-Christine
Clavel-Chapelon, Francoise
Panico, Salvatore
Weiderpass, Elisabete
Lund, Eiliv
Gram, Inger T.
Riboli, Elio
Pawlita, Michael
Waterboer, Tim
Kreimer, Aimee R.
Johansson, Mattias
Brennan, Paul
Title Combined effects of smoking and HPV16 in oropharyngeal cancer
Journal name International Journal of Epidemiology   Check publisher's open access policy
ISSN 0300-5771
1464-3685
Publication date 2016-06-01
Sub-type Article (original research)
DOI 10.1093/ije/dyw069
Open Access Status Not yet assessed
Volume 45
Issue 3
Start page 752
End page 761
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Subject 2713 Epidemiology
Abstract BACKGROUND: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.
Formatted abstract
Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.

Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multicentre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.

Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.

Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.
Keyword Human papillomavirus
Tobacco smoking
Interaction
Head and neck cancer risk
Oropharynx cancer
Human-Papillomavirus Serology
Neck-Cancer
International Agency
Data-Collection
Pooled Analysis
Head
Alcohol
Tobacco
Risk
Association
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 23 May 2017, 13:52:20 EST by Anthony Yeates on behalf of Learning and Research Services (UQ Library)