Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex

Kemper, K. E., Carrick, M. J. and Goddard, M. E. (2015). Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex. In: Iona MacLeod, Proceedings of the Twenty-first (21st) Conference. Association for the Advancement of Animal Breeding and Genetics, Lorne, VIC, Australia, (61-64). 28-30 September 2015.

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Name Description MIMEType Size Downloads
Author Kemper, K. E.
Carrick, M. J.
Goddard, M. E.
Title of paper Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex
Conference name Association for the Advancement of Animal Breeding and Genetics
Conference location Lorne, VIC, Australia
Conference dates 28-30 September 2015
Proceedings title Proceedings of the Twenty-first (21st) Conference
Place of Publication Lorne, VIC, Australia
Publisher Association for the Advancement of Animal Breeding and Genetics
Publication Year 2015
Sub-type Fully published paper
Open Access Status Not yet assessed
ISBN 9780646945545
ISSN 1328-3227
Editor Iona MacLeod
Volume 21
Start page 61
End page 64
Total pages 4
Language eng
Formatted Abstract/Summary
Casein proteins comprise about 80% of the protein in bovine milk. The casein complex occupies a 300 kb region of the genome on BTA6. To disentangle the number of variants affecting protein percentage in bovine milk near the casein complex, we use single variant regressions with imputed full sequence variants and quantified αS1-, β- and κ-casein protein levels in 444 Holstein Friesian cows. We find 2 variants, located near CSN3 (coding κ-casein) and within CSN1S1 (which codes for αS1-casein), with independent effects on P% and which affect concentration of their corresponding casein gene products. Previously described protein polymorphisms in the casein genes were sometimes associated with the quantity of their respective proteins but it seems unlikely that these variants are causing variation in casein concentrations
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes http://www.aaabg.org/aaabghome/AAABG21papers/Kemper21061.pdf

Document type: Conference Paper
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 23 May 2017, 13:36:11 EST by Kathryn Kemper on behalf of Institute for Molecular Bioscience