Nitric oxide, a potent vasodilator of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus

Axelsson, M., Catharina, C., Gibbins, I., Holmgren, S. and Franklin, C. E. (2001) Nitric oxide, a potent vasodilator of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus. General and Comparative Endocrinology, 122 2: 198-204. doi:10.1006/gcen.2001.7627


Author Axelsson, M.
Catharina, C.
Gibbins, I.
Holmgren, S.
Franklin, C. E.
Title Nitric oxide, a potent vasodilator of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus
Journal name General and Comparative Endocrinology   Check publisher's open access policy
ISSN 0016-6480
1095-6840
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1006/gcen.2001.7627
Volume 122
Issue 2
Start page 198
End page 204
Total pages 7
Editor R.M. Dores
I.W. Henderson
Place of publication San Diego, CA, USA
Publisher Academic Press
Collection year 2001
Language eng
Subject 270603 Animal Physiology - Systems
780105 Biological sciences
Abstract The effects of five neuropeptides (CGRP, SOM, SP, NPY, VIP), L-NAME (nitric oxide synthase inhibitor), and adrenaline on the contractile tone of the aortic anastomosis in the estuarine crocodile, Crocodylus porosus, were investigated. None of the neuropeptides, which had previously been found to be present in the aortic anastomosis, had any direct effect on the tension developed by ring preparations. L-NAME itself significantly increased the basal tone of the vascular ring preparations, suggesting a tonic release of nitric oxide in the preparation. Adrenaline produced concentration-dependent vasoconstrictions that were counteracted by profound reflex vasodilatations that were susceptible to blockade by L-NAME. Immunohistochemistry revealed the presence of nitric oxide synthase and tyrosine hydroxylase-containing (indicating the presence of a adrenergic innervation) nerve fibres in the adventitia and adventitio-medial border of the aortic anastomosis. These data demonstrate opposing actions of adrenaline and nitric oxide on the vascular smooth muscle in the anastomosis of the C. porosus. The morphology of the anastomosis, with the extremely thick muscular vessel wall, suggests a sphincter-like function for this vessel that could be controlled mainly by adrenergic and nitrergic mechanisms, (C) 2001 Academic Press.
Keyword Endocrinology & Metabolism
Nitric Oxide
Reptiles
Vasodilatation
Sp
Npy
Cgrp
Vip
Somatostatin
Galanin
Grp
Adrenaline
L-name
Gene-related Peptide
Sensory Neurons
Alligator Heart
Large Arteries
Substance-p
Immunoreactivity
Nerves
Flow
Neuropeptides
Localization
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 15 Aug 2007, 02:28:13 EST