The calibre of the Foramen of Panizza in Crocodylus porosus is variable and under adrenergic control

Axelsson, M. and Franklin, C. E. (2001) The calibre of the Foramen of Panizza in Crocodylus porosus is variable and under adrenergic control. Journal of Comparative Physiology B-biochemical Systemic And Environmental Physiology, 171 4: 341-346. doi:10.1007/s003600100183


Author Axelsson, M.
Franklin, C. E.
Title The calibre of the Foramen of Panizza in Crocodylus porosus is variable and under adrenergic control
Journal name Journal of Comparative Physiology B-biochemical Systemic And Environmental Physiology   Check publisher's open access policy
ISSN 0174-1578
Publication date 2001-05-01
Sub-type Article (original research)
DOI 10.1007/s003600100183
Volume 171
Issue 4
Start page 341
End page 346
Total pages 6
Editor I.D. Hume
L.C. Wang
Place of publication Heidelberg
Publisher Springer-Verlag
Collection year 2001
Language eng
Subject 270603 Animal Physiology - Systems
780105 Biological sciences
Abstract The foramen of Panizza is located within the outflow tract of the crocodilian heart, between the left and right aortas. It has been suggested that the foremen of Panizza has a variable calibre, which could explain the profound changes in the distribution of flows and pressure profiles recorded in the right and left aortas. We investigated this possibility using a modified in-situ perfused heart preparation in combination with isolated strip preparations from the outflow tract. In the perfused heart preparation, bolus injections of adrenaline increased the resistance in the foramen of Panizza, indicating a decrease in its diameter. Isolated strip preparations from the outflow tract showed a concentration-dependent increase in tension in response to adrenaline, while vasoactive intestinal polypeptide caused a relaxation in adrenaline pre-contracted strip preparations. We propose that an increase in the diameter of the foremen of Panizza may be important during pulmonary to systemic shunts to allow blood to flow from the left to right aorta (reverse foramen flow) in order to supply the carotid and coronary arteries. During non-shunting conditions, a constricted foramen may prevent excess flow from the right to left aorta during diastole.
Keyword Physiology
Zoology
Reptile Heart
Haemodynamics
Foramen Of Panizza
VIP
Adrenaline
Perfused Crocodile Heart
Angioscopy
Physiology
Dynamics
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Biological Sciences Publications
Ecology Centre Publications
 
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Created: Wed, 15 Aug 2007, 02:27:58 EST