New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes

Martin, Darren J., Warren, Laura A. Poole, Gunatillake, Pathiraja A., McCarthy, Simon J., Meijs, Gordon F. and Schindhelm, Klaus (2001) New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes. Biomaterials, 22 9: 973-978. doi:10.1016/S0142-9612(00)00262-3

Author Martin, Darren J.
Warren, Laura A. Poole
Gunatillake, Pathiraja A.
McCarthy, Simon J.
Meijs, Gordon F.
Schindhelm, Klaus
Title New methods for the assessment of in vitro and in vivo stress cracking in biomedical polyurethanes
Journal name Biomaterials   Check publisher's open access policy
ISSN 0142-9612
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1016/S0142-9612(00)00262-3
Volume 22
Issue 9
Start page 973
End page 978
Total pages 6
Editor R. S. Langer
N. A. Peppas
Place of publication United Kingdom
Publisher Elsevier
Collection year 2001
Language eng
Subject C1
291503 Biomaterials
680303 Polymeric materials (e.g. paints)
Abstract This article describes a new test method for the assessment of the severity of environmental stress cracking of biomedical polyurethanes in a manner that minimizes the degree of subjectivity involved. The effect of applied strain and acetone pre-treatment on degradation of Pellethane 2363 80A and Pellethane 2363 55D polyurethanes under in vitro and in vivo conditions is studied. The results are presented using a magnification-weighted image rating system that allows the semi-quantitative rating of degradation based on distribution and severity of surface damage. Devices for applying controlled strain to both flat sheet and tubing samples are described. The new rating system consistently discriminated between. the effects of acetone pre-treatments, strain and exposure times in both in vitro and in vivo experiments. As expected, P80A underwent considerable stress cracking compared with P55D. P80A produced similar stress crack ratings in both in vivo and in vitro experiments, however P55D performed worse under in vitro conditions compared with in vivo. This result indicated that care must be taken when interpreting in vitro results in the absence of in vivo data. (C) 2001 Elsevier Science Ltd. All rights reserved.
Keyword Engineering, Biomedical
Materials Science, Biomaterials
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 02:26:23 EST