Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis

Chatterton, Mary Lou, Stockings, Emily, Berk, Michael, Barendregt, Jan J., Carter, Rob and Mihalopoulos, Cathrine (2017) Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis. British Journal of Psychiatry, 210 5: 333-341. doi:10.1192/bjp.bp.116.195321


Author Chatterton, Mary Lou
Stockings, Emily
Berk, Michael
Barendregt, Jan J.
Carter, Rob
Mihalopoulos, Cathrine
Title Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis
Journal name British Journal of Psychiatry   Check publisher's open access policy
ISSN 0007-1250
1472-1465
Publication date 2017-05-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1192/bjp.bp.116.195321
Open Access Status Not yet assessed
Volume 210
Issue 5
Start page 333
End page 341
Total pages 9
Place of publication London, United Kingdom
Publisher Royal College of Psychiatrists
Language eng
Abstract BackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF).ResultsCarer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores.ConclusionsOnly interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
Formatted abstract
Background: Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.

Aims: To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).

Method: Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF).

Results: Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive–behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores.

Conclusions: Only interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Public Health Publications
Admin Only - School of Public Health
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 3 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 21 May 2017, 02:41:13 EST by System User on behalf of Learning and Research Services (UQ Library)