Targeting cancer-related inflammation in the era of immunotherapy

Nakamura, Kyohei and Smyth, Mark J. (2017) Targeting cancer-related inflammation in the era of immunotherapy. Immunology and Cell Biology, 95 4: 325-332. doi:10.1038/icb.2016.126

Author Nakamura, Kyohei
Smyth, Mark J.
Title Targeting cancer-related inflammation in the era of immunotherapy
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 1440-1711
Publication date 2017-04-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/icb.2016.126
Open Access Status Not yet assessed
Volume 95
Issue 4
Start page 325
End page 332
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2403 Immunology
1307 Cell Biology
Abstract Recent advances in cancer immunotherapy, particularly immune checkpoint blockade therapy have dramatically changed the therapeutic strategy against advanced malignancies. Still, only a subset of patients shows a good response to any single therapy. Moreover, it remains largely unsolved how we can maintain durable clinical responses, or how we can successfully treat a broader range of cancers by immunotherapy. Growing evidence suggests that the major barrier to more successful cancer immunotherapy is the tumour microenvironment (TME), where chronic inflammation has a predominant role in tumour survival and proliferation, angiogenesis and immunosuppression. Over the past decades, our understanding of cancer-related inflammation has significantly evolved, and now we have various therapeutic options tailored to the TME. These therapeutic strategies include inhibiting inflammatory mediators or their downstream signalling molecules, blocking the recruitment of myeloid cells, modulating immunosuppressive functions in myeloid cells and re-educating the TME. In this review, we discuss the role of cancer-related inflammation as a potential target in the era of immunotherapy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Clinical Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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