Biomimetic silica nanocapsules for tunable sustained release and cargo protection

Yang, Guang-Ze, Wibowo, David, Yun, Jung-Ho, Wang, Lianzhou, Middelberg, Anton P. J. and Zhao, Chun-Xia (2017) Biomimetic silica nanocapsules for tunable sustained release and cargo protection. Langmuir, 33 23: 5777-5785. doi:10.1021/acs.langmuir.7b00590

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Yang, Guang-Ze
Wibowo, David
Yun, Jung-Ho
Wang, Lianzhou
Middelberg, Anton P. J.
Zhao, Chun-Xia
Title Biomimetic silica nanocapsules for tunable sustained release and cargo protection
Journal name Langmuir   Check publisher's open access policy
ISSN 0743-7463
1520-5827
Publication date 2017-06-13
Year available 2017
Sub-type Article (original research)
DOI 10.1021/acs.langmuir.7b00590
Open Access Status File (Author Post-print)
Volume 33
Issue 23
Start page 5777
End page 5785
Total pages 9
Place of publication Washington, DC, United States
Publisher American Chemical Society
Language eng
Subject 2500 Materials Science
3104 Condensed Matter Physics
3110 Surfaces and Interfaces
1607 Spectroscopy
1603 Electrochemistry
Abstract Silica nanocapsules have attracted tremendous interest for encapsulation, protection and controlled release of various cargoes due to their unique hierarchical core–shell structure. However, it remains challenging to synthesize silica nanocapsules having high cargo-loading capacity and cargo-protection capability without compromising process simplicity and biocompatibility properties. Here, we synthesized oil-core silica-shell nanocapsules under environmentally friendly conditions by a novel emulsion and biomimetic dual-templating approach using a dual-functional protein, in lieu of petrochemical surfactants, thus avoiding the necessities for the removal of toxic components. A light- and pH-sensitive compound can be facilely encapsulated in the silica nanocapsules with the encapsulation efficiency of nearly 100%. Release of the encapsulated active from the nanocapsules was not shown an indication of undesired burst release. Instead, the release can be tuned by controlling the silica-shell thicknesses i.e., 40 and 77 nm from which the cargo released at 42.0 and 31.3% of the initial amount after 32 days, respectively. The release kinetics were fitted well to Higuchi model, enabling the possibility of the prediction of release kinetics as a function of shell thickness thus achieving design-for-purpose silica nanocapsules. Furthermore, the nanocapsules showed excellent alkaline- and sunlight-shielding protective efficacies which resulted in significantly prolonged half-life of the sensitive cargo. Our biomimetic silica nanocapsules provide a nanocarrier platform for applications that demand process scalability, sustainability and biocompatibility coupled with unique cargo-protection and controlled-release properties.
Keyword Silica nanocapsule
Biosilicification
Sustained release
Release kinetics
Sunlight shielding
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID DP150100798
FT140100726
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Chemical Engineering Publications
HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 17 May 2017, 12:55:30 EST by David Wibowo on behalf of Aust Institute for Bioengineering & Nanotechnology