Mimicking the motion of life: catalytically active rotaxanes as processive enzyme mimics

Thordarson, Pall, Nolte, Roeland J. M. and Rowan, Alan E. (2004) Mimicking the motion of life: catalytically active rotaxanes as processive enzyme mimics. Australian Journal of Chemistry, 57 4: 323-327. doi:10.1071/CH03302


Author Thordarson, Pall
Nolte, Roeland J. M.
Rowan, Alan E.
Title Mimicking the motion of life: catalytically active rotaxanes as processive enzyme mimics
Journal name Australian Journal of Chemistry   Check publisher's open access policy
ISSN 0004-9425
1445-0038
Publication date 2004-04-01
Year available 2004
Sub-type Article (original research)
DOI 10.1071/CH03302
Open Access Status Not yet assessed
Volume 57
Issue 4
Start page 323
End page 327
Total pages 5
Place of publication Clayton, VIC, Australia
Publisher C S I R O Publishing
Language eng
Abstract An often overlooked but essential architectural motif found in all living organisms is that of the toroid. Through evolution, nature has used the threading of biopolymers through toroidal assemblies, forming pseudo-rotaxanes, to impart a processive character on the synthesis, replication, repair, and even recombination of DNA. In spite of the fact that numerous processive enzymes have been reported and that life would not exist without such natural rotaxanes, there are virtually no examples of synthetic processive catalysts let alone biomimetic models of these essential and potentially useful systems. To rectify this omission we describe below our recent construction and study of the first catalytic rotaxane molecular machine, which can run along a polymer thread and carry out processive oxidative reactions.
Keyword Chemistry, Multidisciplinary
Chemistry
CHEMISTRY, MULTIDISCIPLINARY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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