Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers

Whitfield, John B., Zhu, Gu, Heath, Andrew C., Martin, Nicholas G. and Powell, Lawrie W. (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcoholism: Clinical and Experimental Research, 25 7: 1037-1045. doi:10.1097/00000374-200107000-00014

Author Whitfield, John B.
Zhu, Gu
Heath, Andrew C.
Martin, Nicholas G.
Powell, Lawrie W.
Title Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers
Journal name Alcoholism: Clinical and Experimental Research   Check publisher's open access policy
ISSN 0145-6008
Publication date 2001-07-01
Year available 2001
Sub-type Article (original research)
DOI 10.1097/00000374-200107000-00014
Open Access Status
Volume 25
Issue 7
Start page 1037
End page 1045
Total pages 9
Editor Marcu A. Rothschild
Place of publication USA
Publisher Williams & Wilkins
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Background: Alcohol increases body iron stores. Alcohol and iron may increase oxidative stress and the risk of alcohol-related liver disease. The relationship between low or safe levels of alcohol use and indices of body iron stores, and the factors that affect the alcohol-iron relationship, have not been fully characterized. Other aspects of the biological response to alcohol use have been reported to depend on iron status. Methods: We have measured serum iron, transferrin, and ferritin as indices of iron stores in 3375 adult twin subjects recruited through the Australian Twin Registry. Information on alcohol use and dependence and smoking was obtained from questionnaires and interviews. Results: Serum iron and ferritin increased progressively across classes of alcohol intake. The effects of beer consumption were greater than those of wine or spirits. Ferritin concentration was significantly higher in subjects who had ever been alcohol dependent. There was no evidence of interactions between HFE genotype or body mass index and alcohol. Alcohol intake-adjusted carbohydrate-deficient transferrin was increased in women in the lowest quartile of ferritin results, whereas adjusted gamma -glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase values were increased in subjects with high ferritin. Conclusions: Alcohol intake at low level increases ferritin and, by inference, body iron stores. This may be either beneficial or harmful, depending on circumstances. The response of biological markers of alcohol intake can be affected by body iron stores; this has implications for test sensitivity and specificity and for variation in biological responses to alcohol use.
Keyword Iron
Biological Markers
Carbohydrate-deficient Transferrin
Serum Ferritin
Liver Iron
Body Iron
Q-Index Code C1
Grant ID AA07535
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Medicine Publications
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 88 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 02:00:58 EST