Non-coding RNAs: the architects of eukaryotic complexity

Mattick, J. S. (2001) Non-coding RNAs: the architects of eukaryotic complexity. Embo Reports, 2 11: 986-991. doi:10.1093/embo-reports/kve230

Author Mattick, J. S.
Title Non-coding RNAs: the architects of eukaryotic complexity
Journal name Embo Reports   Check publisher's open access policy
ISSN 1469-221X
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1093/embo-reports/kve230
Open Access Status Not yet assessed
Volume 2
Issue 11
Start page 986
End page 991
Total pages 6
Place of publication Oxford
Publisher Oxford University Press
Language eng
Subject C1
270205 Genetic Development (incl. Sex Determination)
780105 Biological sciences
Abstract Around 98% of all transcriptional output in humans is noncoding RNA. RNA-mediated gene regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA interference, co-suppression, transgene silencing, imprinting, methylation, and possibly position-effect variegation and transvection, all involve intersecting pathways based on or connected to RNA signaling. I suggest that the central dogma is incomplete, and that intronic and other non-coding RNAs have evolved to comprise a second tier of gene expression in eukaryotes, which enables the integration and networking of complex suites of gene activity. Although proteins are the fundamental effectors of cellular function, the basis of eukaryotic complexity and phenotypic variation may lie primarily in a control architecture composed of a highly parallel system of trans-acting RNAs that relay state information required for the coordination and modulation of gene expression, via chromatin remodeling, RNA-DNA, RNA-RNA and RNA-protein interactions. This system has interesting and perhaps informative analogies with small world networks and dataflow computing.
Keyword Biochemistry & Molecular Biology
Cell Biology
Noncoding Rna
Multifunctional Proteins
Bithorax Complex
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 385 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 15 Aug 2007, 01:57:01 EST