Homozygous Deletions of the Multiple Tumor Suppressor Gene 1 in the Progression of Human Astrocytomas

Walker D.G., Duan W., Popovic E.A., Kaye A.H., Tomlinson F.H. and Lavin M. (1995) Homozygous Deletions of the Multiple Tumor Suppressor Gene 1 in the Progression of Human Astrocytomas. Cancer Research, 55 1: 20-23.

Author Walker D.G.
Duan W.
Popovic E.A.
Kaye A.H.
Tomlinson F.H.
Lavin M.
Title Homozygous Deletions of the Multiple Tumor Suppressor Gene 1 in the Progression of Human Astrocytomas
Journal name Cancer Research   Check publisher's open access policy
ISSN 1538-7445
Publication date 1995-02-01
Year available 1995
Sub-type Article (original research)
Volume 55
Issue 1
Start page 20
End page 23
Total pages 4
Place of publication PHILADELPHIA
Publisher AMER ASSOC CANCER RESEARCH
Language eng
Abstract The multiple tumor suppressor gene 1 (MTS1) located on chromosome 9p has recently been implicated as a candidate tumor suppressor gene in many different tumor types, Cytogenetic analysis and deletion mapping studies have revealed that deletion of chromosome 9p occurs in a significant number of primary human astrocytomas, Using multiplex PCR with primers for exon 2 of MTS1 and for D9S196 from chromosome 9q, we have analyzed 78 primary astrocytic tumors for the deletion of MTS1. After controlling for the contamination of tumor samples with normal cells, homozygous loss of MTS1 was found in 13 of 25 anaplastic astrocytomas (WHO grade III) and in 27 of 46 cases of glioblastomas (WHO grade TV) but in none of seven astrocytomas (WHO grade IT), These data suggest that MTS1 is an important tumor suppressor gene in the malignant progression of astrocytomas.
Keyword Critical Region
Gliomas
Heterogeneity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import - Archived
 
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