Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium

Satarug, S, Baker, JR, Reilly, PEB, Moore, MR and Williams, DJ (2001) Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium. Human & Experimental Toxicology, 20 4: 205-213. doi:10.1191/096032701678766787


Author Satarug, S
Baker, JR
Reilly, PEB
Moore, MR
Williams, DJ
Title Changes in zinc and copper homeostasis in human livers and kidneys associated with exposure to environmental cadmium
Journal name Human & Experimental Toxicology   Check publisher's open access policy
ISSN 0144-5952
0960-3271
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1191/096032701678766787
Open Access Status DOI
Volume 20
Issue 4
Start page 205
End page 213
Total pages 9
Place of publication London, UK
Publisher Arnold Hodder Headline PLC
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730200 Public Health
Abstract This study was undertaken to assess changes in zinc and copper homeostasis in human tissues that could be attributed to human exposure to environmental cadmium, using samples of lung, liver and kidney cortex of 61 Queensland residents, aged 2 to 89 years, who had died of accidental causes. None of the subjects were exposed to cadmium in the workplace. Levels of zinc in liver and kidney cortex samples showed inverse associations with donor age whereas zinc in lung only showed inverse association with gender. Lung zinc levels in females were 14% lower than in males. Zinc in liver and kidney cortex samples were found to exist in at least two pools; one was associated with cadmium that bound to metallothionein (MT) and the other was associated with non - MTbound copper. In liver, the amounts of zinc in the MT pool were smaller compared to those in non-MT pool given that only 7% of zinc variations were explained by cadmium whereas 22% of the liver zinc Variations were accounted for by non - MT bound copper. In sharp contrast, larger amounts of zinc in kidney cortex samples were in the MT pool, compared to those in the non-MT pool given that cadmium was found to explain 69% of total zinc variation whereas copper explained only 17% of kidney zinc variations. The levels of copper in liver were found to be increased by 45-50% in subjects with high cadmium exposure level, compared to subjects of similar ages with medium exposure level. The levels of zinc and copper in kidney cortex samples in the subjects with high cadmium exposure were both found to be significantly elevated compared to those found in the medium-exposure group whereas copper contents were about 19-23% greater than in medium- as well as low-exposure groups. Taken together these results indicate increased sequestration of zinc and copper in liver and kidney cortex samples. The increases in metal sequestrations were observed in liver samples having cadmium contents of greater than 1 mug/g wet weight and in kidney cortex having cadmium contents of greater than 26 mug/g wet weight. Zinc and copper contents in lung of this sample group, however, were not associated with cadmium due probably to lower exposure levels compared to those of liver and kidney.
Keyword Toxicology
Cadmium Body Burden
Human Autopsy
Zinc
Copper
Metal Homeostasis
Metal Toxicity
Chronic Low-level Exposure
Liver
Kidney
Metallothionein Levels
Nitric-oxide
Regression Analysis
Renal Dysfunction
Diabetes-mellitus
Body Burden
Toxicity
Population
Metals
Time
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: National Research Centre for Environmental Toxicology Publications
 
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Created: Wed, 15 Aug 2007, 01:48:52 EST