Molecular basis by which garlic suppresses atherosclerosis

Campbell, J. H., Efendy, J., Smith, N. J. and Campbell, G. R. (2001) Molecular basis by which garlic suppresses atherosclerosis. Journal of Nutrition, 131 131: 1006S-1009S.

Author Campbell, J. H.
Efendy, J.
Smith, N. J.
Campbell, G. R.
Title Molecular basis by which garlic suppresses atherosclerosis
Journal name Journal of Nutrition   Check publisher's open access policy
ISSN 0022-3166
Publication date 2001-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 131
Issue 131
Start page 1006S
End page 1009S
Total pages 4
Editor John A Milner
Place of publication Bethesada
Publisher American Society for Nutritional Sciences
Language eng
Subject C1
730106 Cardiovascular system and diseases
321003 Cardiology (incl. Cardiovascular Diseases)
Abstract The aim of this study was to determine the mechanism by which the aged garlic extract Kyolic has a protective effect against atherosclerosis. Plasma cholesterol of rabbits fed a 1% cholesterol-enriched diet for 6 wk was not reduced by supplementation with 800 muL Kyolic/(kg body . d). In spite of this, Kyolic reduced by 64% (P < 0.05) the surface area of the thoracic aorta covered by fatty streaks and significantly reduced aortic arch cholesterol. Kyolic also significantly inhibited by 50% the development of thickened, lipid-filled lesions in preformed neointimas produced by Fogarty 2F balloon catheter injury of the right carotid artery in cholesterol-fed rabbits. In vitro studies found that Kyolic completely prevented vascular smooth muscle phenotypic change from the contractile. high volume fraction of filament (V(v)myo) state, and inhibited proliferation of smooth muscle cells in the synthetic state with a 50% effective dose (ED50) of 0.2%. Kyolic also slightly inhibited the accumulation of lipid in cultured macrophages but not smooth muscle, and had no effect an the expression of adhesion molecules on the surface of the endothelium or the adherence of leukocytes. It is concluded that Kyolic exerts antiatherogenic effects through inhibition of smooth muscle phenotypic change and proliferation, and by another (unclarified) effect on lipid accumulation in the artery wall.
Keyword Nutrition & Dietetics
Smooth Muscle
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
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Created: Wed, 15 Aug 2007, 01:46:44 EST