First report of the cyanotoxins cylindrospermopsin and deoxycylindrospermopsin from Raphidiopsis curvata (Cyantobacteria)

Li, Renhui, Carmichael, Wayne W., Brittain, Scott, Eaglesham, Geoffrey K., Shaw, Glen R., Liu, Yongding and Watanabe, Makoto M. (2001) First report of the cyanotoxins cylindrospermopsin and deoxycylindrospermopsin from Raphidiopsis curvata (Cyantobacteria). Journal of Phycology, 37 6: 1121-1126. doi:10.1046/j.1529-8817.2001.01075.x


Author Li, Renhui
Carmichael, Wayne W.
Brittain, Scott
Eaglesham, Geoffrey K.
Shaw, Glen R.
Liu, Yongding
Watanabe, Makoto M.
Title First report of the cyanotoxins cylindrospermopsin and deoxycylindrospermopsin from Raphidiopsis curvata (Cyantobacteria)
Journal name Journal of Phycology   Check publisher's open access policy
ISSN 0022-3646
1529-8817
Publication date 2001-12-01
Sub-type Article (original research)
DOI 10.1046/j.1529-8817.2001.01075.x
Open Access Status Not Open Access
Volume 37
Issue 6
Start page 1121
End page 1126
Total pages 6
Place of publication Malden, Mass., U.S.A.
Publisher Blackwell Science Inc
Language eng
Subject C1
321299 Public Health and Health Services not elsewhere classified
730210 Environmental health
Abstract A strain of Raphidiopsis (Cyanobacteria) isolated from a fish pond in Wuhan, P. R. China was examined for its taxonomy and production of the alkaloidal hepatotoxins cylindrospermopsin (CYN) and deoxy-cylindrospermopsin (deoxy-CYN). Strain HB1 was identified as R. curvata Fritsch et Rich based on morphological examination of the laboratory culture. HB1 produced mainly deoxy-CYN at a concentration of 1.3 mg(.)g(-1) (dry ut cells) by HPLC and HPLC-MS/MS. CYN was also detected in trace amounts (0.56 mug(.)g(-1)). A mouse bioassay did not show lethal toxicity when tested at doses up to 1500 mg dry weight cells(.)kg(-1) body weight within 96 h, demonstrating that production of primarily deoxy CYN does not lead to significant mouse toxicity by strain BB I. The presence of deoxy-CYN and CYN in R curvata suggests that Raphidiopsis belongs to the Nostocaceae, but this requires confirmation by molecular systematic studies. Production of these cyanotoxins by Raphidiopsis adds another genus, in addition to Cylindrospemopsis, Aphanizomenon, and Umezakia, now known to produce this group of hepatotoxic cyanotoxins. This is also the first report from China of a CYN and deoxy-CYN producing cyanobacterium.
Keyword Plant Sciences
Marine & Freshwater Biology
China
Cyanotoxin
Cylindrospermopsin (cyn)
Deoxycylindrospermopsin (deoxy-cyn)
Cyanobacteria
Raphdiopsis Curvata
Cyanobacterium
Raciborskii
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
 
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Created: Wed, 15 Aug 2007, 01:44:20 EST