The pyramidal cell in cognition: A comparative study in human and monkey

Elston, Guy N., Benavides-Piccione, Ruth and DeFelipe, Javier (2001) The pyramidal cell in cognition: A comparative study in human and monkey. Journal of Neuroscience, 21 17: .

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Author Elston, Guy N.
Benavides-Piccione, Ruth
DeFelipe, Javier
Title The pyramidal cell in cognition: A comparative study in human and monkey
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2001-01-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 21
Issue 17
Total pages 5
Editor Shepherd
Place of publication Washington DC, USA
Publisher Society for Neuroscience, Highwire Press
Language eng
Subject C1
320702 Central Nervous System
780108 Behavioural and cognitive sciences
Abstract Here we present evidence that the pyramidal cell phenotype varies markedly in the cortex of different anthropoid species. Regional and species differences in the size of, number of bifurcations in, and spine density of the basal dendritic arbors cannot be explained by brain size. Instead, pyramidal cell morphology appears to accord with the specialized cortical function these cells perform. Cells in the prefrontal cortex of humans are more branched and more spinous than those in the temporal and occipital lobes. Moreover, cells in the prefrontal cortex of humans are more branched and more spinous than those in the prefrontal cortex of macaque and marmoset monkeys. These results suggest that highly spinous, compartmentalized, pyramidal cells (and the circuits they form) are required to perform complex cortical functions such as comprehension, perception, and planning.
Keyword Neurosciences
Cortex
Dendrite
Spine
Primate
Macaque
Marmoset
Prefrontal
Temporal
Occipital
Short-term-memory
Macaque Monkey
Cerebral-cortex
Dendritic Spines
Frontal-cortex
Visual-cortex
Visuotopic Organization
Prefrontal Cortex
Synaptic Density
Marmoset Monkey
Q-Index Code C1
Additional Notes article number: RC-123

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biomedical Sciences Publications
 
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Created: Wed, 15 Aug 2007, 01:35:51 EST