Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas

Arnold, J. M., Cummings, M., Purdie, D. and Chenevix-Trench, G. (2001) Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas. British Journal of Cancer, 85 9: 1351-1358. doi:10.1054/bjoc.2001.2075

Author Arnold, J. M.
Cummings, M.
Purdie, D.
Chenevix-Trench, G.
Title Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1054/bjoc.2001.2075
Open Access Status DOI
Volume 85
Issue 9
Start page 1351
End page 1358
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Ovarian adenocarcinomas develop as the result of multiple genetic, and epigenetic changes in the precursor ovarian surface epithelial (OSE) cells which result in a malignant phenotype. We investigated changes in gene expression in ovarian adenocarcinoma using a cDNA array containing 588 known human genes. We found that intercellular adhesion molecule-1 (ICAM-1) was expressed at lower levels in the ovarian tumour cell lines OAW42, PEO1 and JAM than in the immortalised human ovarian surface epithelial cell line HOSE 17.1. Further investigation revealed ICAM-1 was expressed in the surface epithelium of normal ovaries and both mRNA and protein expression levels were reduced in the majority of ovarian adenocarcinoma cell lines and primary tumours. ICAM-1 expression was increased in 8/8 cell lines treated with the de novo methyltransferase inhibitor 5-aza-2'-deoxycytidiine, indicating that methylation of CpG islands may play a role in the down-regulation of its expression in primary tumours. 'There was a significant association between patients whose tumours expressed ICAM-1 and survival (P = 0.03), suggesting that expression levels of ICAM-1 may have clinical relevance. (C) 2001 Cancer Research Campaign.
Keyword Oncology
Ovarian Adenocarcinoma
5-aza-2 '-deoxycytidine
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Public Health Publications
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Created: Wed, 15 Aug 2007, 01:32:15 EST