No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer

Spurdle, Amanda B., Webb, Penelope M., Purdie, David M., Chen, Xiaoqing, Green, Adele and Chenevix-Trench, Georgia (2001) No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer. Carcinogenesis, 22 5: 717-721. doi:10.1093/carcin/22.5.717


Author Spurdle, Amanda B.
Webb, Penelope M.
Purdie, David M.
Chen, Xiaoqing
Green, Adele
Chenevix-Trench, Georgia
Title No significant association between progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of ovarian cancer
Journal name Carcinogenesis   Check publisher's open access policy
ISSN 1460-2180
1460-2180
Publication date 2001-05-01
Sub-type Article (original research)
DOI 10.1093/carcin/22.5.717
Open Access Status Not Open Access
Volume 22
Issue 5
Start page 717
End page 721
Total pages 5
Place of publication Oxford, UK
Publisher Oxford University Press
Language eng
Subject C1
321015 Oncology and Carcinogenesis
730108 Cancer and related disorders
Abstract Epidemiological studies suggest that ovarian cancer is an endocrine-related tumour, and progesterone exposure specifically may decrease the risk of ovarian cancer. To assess whether the progesterone receptor (PR) exon 4 valine to leucine amino acid variant is associated with specific tumour characteristics or with overall risk of ovarian cancer, we examined 551 cases of epithelial ovarian cancer and 298 unaffected controls for the underlying G-->T nucleotide substitution polymorphism. Stratification of the ovarian cancer cases according to tumour behaviour (low malignant potential or invasive), histology, grade or stage failed to reveal any heterogeneity with respect to the genotype defined by the PR exon 4 polymorphism. Furthermore, the genotype distribution did not differ significantly between ovarian cancer cases and unaffected controls. Compared with the GG genotype, the age-adjusted odds ratio (95% confidence interval) for risk of ovarian cancer was 0.78 (0.57-1.08) for the GT genotype, and 1.39 (0.47-4.14) for the TT genotype. In conclusion, the PR exon 4 codon 660 leucine variant encoded by the T allele does not appear to be associated with ovarian tumour behaviour, histology, stage or grade. This variant is also not associated with an increased risk of ovarian cancer, and is unlikely to be associated with a large decrease in ovarian cancer risk, although we cannot rule out a moderate inverse association between the GT genotype and ovarian cancer.
Keyword Oncology
Fragment-length-polymorphism
Gene
Mutations
Tumors
Heterozygosity
Insertion
Carcinoma
Survival
Breast
Q-Index Code C1

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 15 Aug 2007, 01:31:34 EST