Innate lymphoid cells: new paradigm in immunology of inflammation

Kumar, Vijay (2014) Innate lymphoid cells: new paradigm in immunology of inflammation. Immunology Letters, 157 1-2: 23-37. doi:10.1016/j.imlet.2013.11.003


Author Kumar, Vijay
Title Innate lymphoid cells: new paradigm in immunology of inflammation
Journal name Immunology Letters   Check publisher's open access policy
ISSN 0165-2478
1879-0542
Publication date 2014-01-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.imlet.2013.11.003
Open Access Status Not yet assessed
Volume 157
Issue 1-2
Start page 23
End page 37
Total pages 15
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Abstract Immune system is well characterized by immunologists into two major arms called innate immunity and adaptive immunity. However, recent advances in the field of immunology has led to the identification of specific immune cells, which lack signature signs of mature lymphocytes (i.e. antigen receptors), yet produce major cytokines (i.e. IFN-γ, IL-4, IL-5, IL-13, IL-9, etc.) of helper T (Th) cell mediated immune response. Therefore, these cells can be represented as the innate counterpart of helper T cells of adaptive immunity and are known as innate lymphoid cells (ILCs). These ILCs comprise of three different groups having different kinds of cells, i.e. group 1 (NK cells and ILC1 cells), group 2 and group 3 ILCs. However, they are also emerging as novel regulators of both chronic as well as acute inflammation induced by infection or caused by sterile inflammation. Therefore, an attempt has been made to highlight the regulatory role of ILCs during inflammation and modulation of these cells as novel tissue protective mechanism.
Keyword Chemokines
Cytokines
ILCs
Infection
Inflammation
LTi cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Child Health Research Centre Publications
 
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