Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study

Hay, D., Martin, N. G., Foley, D., Treloar, S. A., Kirk, K. M. and Heath, A. C. (2001) Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study. Twin Research, 4 1: 30-40. doi:10.1375/twin.4.1.30


Author Hay, D.
Martin, N. G.
Foley, D.
Treloar, S. A.
Kirk, K. M.
Heath, A. C.
Title Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study
Journal name Twin Research   Check publisher's open access policy
ISSN 1369-0523
Publication date 2001-01-01
Sub-type Article (original research)
DOI 10.1375/twin.4.1.30
Open Access Status Not yet assessed
Volume 4
Issue 1
Start page 30
End page 40
Total pages 11
Place of publication Queensland
Publisher Australian Academic Press
Language eng
Subject C1
321011 Medical Genetics
730107 Inherited diseases (incl. gene therapy)
Abstract Previous genetic analyses of psychosis proneness have been limited by their small sample size. For the purposes of large-scale screening, a 12-item questionnaire was developed through a two-stage process of reduction from the full Chapman and Chapman scales. 3685 individuals (including 1438 complete twin pairs) aged 18–25 years and enrolled in the volunteer Australian Twin Registry returned a mail questionnaire which included this psychosis proneness scale and the Eysenck Personality Questionnaire. Despite the brevity of the questionnaire, item and factor analysis identified four unambiguous and essentially uncorrelated scales. There were (1) Perceptual Aberration – Magical Ideation; (2) Hypomania – Impulsivity/Nonconformity; (3) Social Anhedonia and (4) Physical Anhedonia. Model-fitting analyses showed additive genetic and specific environmental factors were sufficient for three of the four scales, with the Social Anhedonia scale requiring also a parameter for genetic dominance. There was no evidence for the previously hypothesised sex differences in the genetic determination of psychosis-proneness. The potential value of multivariate genetic analysis to examine the relationship between these four scales and dimensions of personality is discussed. The growing body of longitudinal evidence on psychosis-proneness suggests the value of incorporating this brief measure into developmental twin studies.
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Public Health Publications
School of Medicine Publications
School of Psychology Publications
 
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Created: Wed, 15 Aug 2007, 01:11:24 EST