Proximal arterial vasoconstriction precedes regression of the hyaloid vasculature

Browning, J., Reichelt, M. E., Gole, G. A. and Massa, H. (2001) Proximal arterial vasoconstriction precedes regression of the hyaloid vasculature. Current Eye Research, 22 6: 405-411. doi:10.1076/ceyr.22.6.405.5482

Author Browning, J.
Reichelt, M. E.
Gole, G. A.
Massa, H.
Title Proximal arterial vasoconstriction precedes regression of the hyaloid vasculature
Journal name Current Eye Research   Check publisher's open access policy
ISSN 0271-3683
Publication date 2001-01-01
Year available 2001
Sub-type Article (original research)
DOI 10.1076/ceyr.22.6.405.5482
Open Access Status Not Open Access
Volume 22
Issue 6
Start page 405
End page 411
Total pages 7
Place of publication Netherlands
Publisher Swets & Zeitlinger
Language eng
Subject C1
320705 Sensory Systems
730111 Hearing, vision, speech and their disorders
1113 Ophthalmology and Optometry
Abstract Purpose: To determine whether constriction of proximal arterial vessels precedes involution of the distal hyaloid vasculature in the mouse, under normal conditions, and whether this vasoconstriction is less pronounced when the distal hyaloid network persists, as it does in oxygen-induced retinopathy (OIR). Methods: Photomicrographs of the vasa hyaloidea propria were analysed from pre-term pups (1-2 days prior to birth), and on Days 1-11 post-birth. The OIR model involved exposing pups to similar to 90% O-2 from D1-5, followed by return to ambient air. At sampling times pups were anaesthetised and perfused with india ink. Retinal flatmounts were also incubated with FITC-lectin (BS-1, G. simplicifolia,); this labels all vessels, allowing identification of vessels not patent to the perfusate. Results: Mean diameter of proximal hyaloid vessels in preterm pups was 25.44 +/- 1.98 mum; +/-1 SEM). Within 3-12 hrs of birth, significant vasoconstriction was evident (diameter:12.45 +/- 0.88 mum), and normal hyaloid regression subsequently occurred. Similar vasoconstriction occurred in the O-2-treated group, but this was reversed upon return to room air, with significant dilation of proximal vessels by D7 (diameter: 31.75 +/- 11.99 mum) and distal hyaloid vessels subsequently became enlarged and tortuous. Conclusions: Under normal conditions, vasoconstriction of proximal hyaloid vessels occurs at birth, preceding attenuation of distal hyaloid vessels. Vasoconstriction also occurs in O-2-treated pups during treatment, but upon return to room air, the remaining hyaloid vessels dilate proximally, and the distal vessels become dilated and tortuous. These observations support the contention that regression of the hyaloid network is dependent, in the first instance, on proximal arterial vasoconstriction.
Keyword Ophthalmology
Arterial Vasoconstriction
Oxygen-induced Retinopathy
Endothelial Growth-factor
Q-Index Code C1
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 15 Aug 2007, 01:06:13 EST