Growth hormone therapy in Prader-Willi Syndrome

Davies, P.S.W. (2001) Growth hormone therapy in Prader-Willi Syndrome. International Journal of Obesity, 25 1: 2-7. doi:10.1038/sj.ijo.0801518

Author Davies, P.S.W.
Title Growth hormone therapy in Prader-Willi Syndrome
Journal name International Journal of Obesity   Check publisher's open access policy
ISSN 0307-0565
Publication date 2001-01-01
Year available 2001
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/sj.ijo.0801518
Open Access Status Not Open Access
Volume 25
Issue 1
Start page 2
End page 7
Total pages 6
Editor Richard Atkinson
Ian MacDonald
Michael J. Stock
Place of publication Stockton, England
Publisher Macmillan
Language eng
Subject C1
321019 Paediatrics
730204 Child health
11 Medical and Health Sciences
1111 Nutrition and Dietetics
Abstract Prader-Willi syndrome (PWS) was originally described less than 50 y ago,1 although reference to children with characteristics of the syndrome are to be found in other literature previous to this.2 Until relatively recently the diagnosis was made upon the clinical features as outlined by Holm,3 which include severe muscular hypotonia in the neonatal period leading to feeding difficulties and undernutrition, hypogonadism and later hyperphagia and obesity. Latterly the syndrome has been identified as being associated with an interstitial deletion of the q11-13 region on chromosome 15.4 In the majority of cases the deletion is in the paternally derived chromosome. In the remainder of cases there seems to be a failure to inherit the entire paternal chromosome and as a consequence both the chromosomes inherited are maternal, thus leading to maternal disomy.
Keyword Endocrinology & Metabolism
Nutrition & Dietetics
Gh-releasing Hormone
Q-Index Code C1
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
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Created: Wed, 15 Aug 2007, 01:04:28 EST