Exercise improves VO2max and body composition in ADT-treated prostate cancer patients

Wall, Bradley A., Galvao, Daniel A., Fatehee, Naeem, Taaffe, Dennis R., Spry, Nigel , Joseph, David, Hebert, Jeffrey J. and Newton, Robert U. (2017) Exercise improves VO2max and body composition in ADT-treated prostate cancer patients. Medicine and Science in Sports and Exercise, 49 8: 1503-1510. doi:10.1249/MSS.0000000000001277


Author Wall, Bradley A.
Galvao, Daniel A.
Fatehee, Naeem
Taaffe, Dennis R.
Spry, Nigel
Joseph, David
Hebert, Jeffrey J.
Newton, Robert U.
Title Exercise improves VO2max and body composition in ADT-treated prostate cancer patients
Formatted title
Exercise improves VO2max and body composition in ADT-treated prostate cancer patients
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 1530-0315
0195-9131
Publication date 2017-03-01
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000001277
Open Access Status Not yet assessed
Volume 49
Issue 8
Start page 1503
End page 1510
Total pages 29
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2732 Orthopedics and Sports Medicine
3612 Physical Therapy, Sports Therapy and Rehabilitation
Abstract Introduction Prostate cancer is the most common cancer in men, and patients treated with androgen deprivation therapy (ADT) experience unfavorable changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population. Methods Ninety-seven men (43-90 yr) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n = 50) or usual care (CON, n = 47). Supervised exercise was undertaken twice weekly at moderate to high intensity. Measures of cardiorespiratory capacity (VO 2max), resting metabolic rate, central blood pressure, hemodynamic variables, blood markers, and body composition were assessed. Results There was a significant group-time interaction present for VO 2max (P = 0.033) with a treatment effect for EX of 0.11 L·min -1 (95% confidence interval [CI] = 0.04-0.19) (relative to body mass = 1.3 mL·kg -1·min -1, 95% CI = 0.3-2.3) and fat oxidation (P = 0.037) of 12.0 mg·min -1 (95% CI = 2.3-21.7). Similarly, there was a significant improvement in glucose (P < 0.001) for EX of -0.5 mmol·L -1 (95% CI = -0.8 to -0.3), with no change in prostate-specific antigen or testosterone as a result of exercise. Body composition was enhanced for EX with adjusted mean differences in lean mass (P = 0.015) of 0.8 kg (95% CI = 0.3-1.3), total fat mass (P = 0.020) of -1.1 kg (95% CI = -1.8 to -0.5), and trunk fat mass (P < 0.001) of -1.0 kg (95% CI = -1.4 to -0.6). Conclusion A 6-month combined aerobic and resistance exercise program has a significant favorable effect on cardiorespiratory capacity, resting fat oxidation, glucose, and body composition despite the adverse effects of hormone suppression. Combined aerobic and resistance training should be considered a key adjuvant component in men undergoing ADT for the treatment of prostate cancer.
Formatted abstract
Introduction: Prostate cancer is the most common cancer in men and patients treated with androgen deprivation therapy (ADT) experience unfavourbale changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population.

Methods: Ninety-seven men (43-90 years) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n=50) or usual care (CON, n=47). Supervised exercise was undertaken twice-weekly at moderate-to-high intensity. Measures of cardiorespiratory capacity (VO2max), resting metabolic rate, central blood pressure, hemodynamic variables, blood markers, and body composition were assessed.

Results: There was a significant group by time interaction present for VO2max (p=0.033) with a treatment effect for EX of 0.11 (95% CI, 0.04-0.19) L.min-1 [relative to body mass 1.3 (95% CI, 0.3-2.3) ml.kg-1.min-1], and fat oxidation (p=0.037) of 12.0 (95% CI, 2.3-21.7) mg.min-1. Similarly, there was a significant improvement in glucose (p<0.001) for EX of -0.5 (95% CI, -0.8 to -0.3) mmol/L, with no change in PSA or testosterone as a result of exercise. Body composition was enhanced for EX with adjusted mean differences in lean mass (p=0.015) of 0.8 (95% CI, 0.3-1.3) kg, total fat mass (p=0.020) of -1.1 (95% CI, -1.8 to -0.5) kg, and trunk fat mass (p<0.001) of -1.0 (95% CI, -1.4 to -0.6) kg.

Conclusions: A 6-month combined aerobic and resistance exercise program has a significant favorable impact on cardiorespiratory capacity, resting fat oxidation, glucose and body composition despite the adverse effects of hormone suppression. Combined aerobic and resistance training should be considered a key adjuvant component in men undergoing ADT for the treatment of prostate cancer.
Keyword Cardiovascular disease
Randomized controlled trial
Aerobic
Resistance
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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