Epidemiology of 45,616 suspect cases of hand, foot and mouth disease in Chongqing, China, 2011-2015

Tao, Jian, He, Xiao-yan, Shi, Yu, Zhu, Guohun, Liu, Shan, Zhang, Zhenzhen, Tang, Shi, Zhang, Rong, Peng, Bin, Liu, Zhidai, Tan, Junjie, Chen, Qian, Wang, Xingbin, Bao, Liming, Zou, Lin and Zhang, Penghui (2017) Epidemiology of 45,616 suspect cases of hand, foot and mouth disease in Chongqing, China, 2011-2015. Scientific Reports, 7 45630. doi:10.1038/srep45630

Author Tao, Jian
He, Xiao-yan
Shi, Yu
Zhu, Guohun
Liu, Shan
Zhang, Zhenzhen
Tang, Shi
Zhang, Rong
Peng, Bin
Liu, Zhidai
Tan, Junjie
Chen, Qian
Wang, Xingbin
Bao, Liming
Zou, Lin
Zhang, Penghui
Title Epidemiology of 45,616 suspect cases of hand, foot and mouth disease in Chongqing, China, 2011-2015
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2017-04-19
Sub-type Article (original research)
DOI 10.1038/srep45630
Open Access Status DOI
Volume 7
Start page 45630
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 1000 General
Abstract Epidemiology and etiology of hand, foot, and mouth disease (HFMD) based on large sample size or evaluation of detection for more enterovirus serotypes are not well investigated in Chongqing of China. 45,616 suspect HFMD patients were prospectively enrolled among whom 21,615 were laboratory confirmed HFMD cases over a 5-year period (January 2011 to December 2015). Their epidemiological, clinical, and laboratory data were extracted and stratified by month, age, sex, disease severity, and enterovirus serotype. Subsequently 292 non-EV-A71/CV-A16 HFMD confirmed cases were randomly selected in three consecutive outbreaks to detect CV-A6 and CV-A10, using RT-PCR. Results showed that the HFMD epidemic peaked in early summer and autumn. The median age of onset was 2.45 years with a male-To-female ratio of 1.54:1, and with children under 5 years of age accounting for 92.54% of all confirmed cases. EV-A71 and CV-A16 infection accounted for only 36.05% (7793/21615) of total confirmed cases while EV-A71 accounted for 59.64% (232/389) of severe cases. Importantly, the proportion of EV-A71 infection generally increased with age which showed rapid growth in severe cases. CV-A6 and CV-A10 were tested positive in Chongqing, but CV-A6 had greater positive rates of 62.33% while CV-A10 had 4.79% in non-EV-A71/CV-A16 HFMD confirmed cases.
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 81373444
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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School of Information Technology and Electrical Engineering Publications
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