Differential expression of Egr-1-like DNA-binding activities in the naive rat brain and after excitatory stimulation

Beckmann, AM, Davidson, MS, Goodenough, S and Wilce, PA (1997) Differential expression of Egr-1-like DNA-binding activities in the naive rat brain and after excitatory stimulation. Journal of Neurochemistry, 69 6: 2227-2237.

Author Beckmann, AM
Davidson, MS
Goodenough, S
Wilce, PA
Title Differential expression of Egr-1-like DNA-binding activities in the naive rat brain and after excitatory stimulation
Journal name Journal of Neurochemistry   Check publisher's open access policy
ISSN 0022-3042
Publication date 1997-01-01
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 69
Issue 6
Start page 2227
End page 2237
Total pages 11
Language eng
Abstract Egr-1 and related proteins are inducible transcription factors within the brain recognizing the same consensus DNA sequence. Three Egr DNA-binding activities were observed in regions of the naive rat brain. Egr-1 was present in all brain regions examined. Bands composed, at least in part, of Egr-2 and Egr-3 were present in different relative amounts in the cerebral cortex, striatum, hippocampus, thalamus, and midbrain. All had similar affinity and specificity for the Egr consensus DNA recognition sequence. Administration of the convulsants NMDA, kainate, and pentylenetetrazole differentially induced Egr-1 and Egr-2/3 DNA-binding activities in the cerebral cortex, hippocampus, and cerebellum. All convulsants induced Egr-1 and Egr-2 immunoreactivity in the cerebral cortex and hippocampus. These data indicate that the members of the Egr family are regulated at different levels and may interact at promoters containing the Egr consensus sequence to fine tune a program of gene expression resulting from excitatory stimuli.
Keyword Biochemistry & Molecular Biology
Neurosciences
Immediate Early Gene
Transcription Factor
Ngfi-a
Nmda
Kainic Acid
Pentylenetetrazole
Immediate-early Gene
Central-nervous-system
Finger Transcription Factors
Ngfi-a Egr-1
Messenger-rna
Limbic Seizures
C-fos
Protein
Growth
Krox-20
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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Created: Tue, 14 Aug 2007, 03:02:32 EST