Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos

Vervoort, M, Merritt, DJ, Ghysen, A and DamblyChaudiere, C (1997) Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos. Development, 124 14: 2819-2828.

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Author Vervoort, M
Merritt, DJ
Ghysen, A
DamblyChaudiere, C
Title Genetic basis of the formation and identity of type I and type II neurons in Drosophila embryos
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 1997-01-01
Year available 1997
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 124
Issue 14
Start page 2819
End page 2828
Total pages 10
Place of publication CAMBRIDGE
Language eng
Abstract The embryonic peripheral nervous system of Drosophila contains two main types of sensory neurons: type I neurons, which innervate external sense organs and chordotonal organs, and type II multidendritic neurons, Here, we analyse the origin of the difference between type I and type II in the case of the neurons that depend on the proneural genes of the achaete-scute complex (ASC), We show that, in Notch(-) embryos, the type I neurons are missing while type nr neurons are produced in excess, indicating that the type I/type II choice relies on Notch-mediated cell communication, In contrast, both type I and type II neurons are absent in numb(-) embryos and after ubiquitous expression of tramtrack, indicating that the activity of numb and the absence of tramtrack are required to produce both external sense organ and multidendritic neural fates, The analysis of string(-) embryos reveals that when the precursors are unable to divide they differentiate mostly into type II neurons, indicating that the type II is the default neuronal fate, We also report a new mutant phenotype where the ASC-dependent neurons are converted into-type II neurons, providing evidence for the existence of one or more genes required for maintaining the alternative (type I) fate, Our results suggest that the same mechanism of type I/type II specification may operate at a late step of the ASC-dependent lineages, when multidendritic neurons arise as siblings of the external sense organ neurons and, at an early step, when other multidendritic neurons precursors arise as siblings of external sense organ precursors.
Keyword Developmental Biology
Sense Organ
Neuronal Identity
Cell Fate Determination
Peripheral Nervous-system
Asymmetric Cell Divisions
Achaete-scute System
Sensory Neurons
Proneural Gene
Sensillum Development
Central Projections
Fate Specification
Organ Formation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Biological Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 14 Aug 2007, 02:54:59 EST