Synthesis of alpha-aspartyl-containing cyclic peptides

Meutermans, WDF, Alewood, PF, Bourne, GT, Hawkins, B and Smythe, ML (1997) Synthesis of alpha-aspartyl-containing cyclic peptides. Letters In Peptide Science, 4 2: 79-84. doi:10.1023/A:1008878017315


Author Meutermans, WDF
Alewood, PF
Bourne, GT
Hawkins, B
Smythe, ML
Title Synthesis of alpha-aspartyl-containing cyclic peptides
Journal name Letters In Peptide Science   Check publisher's open access policy
ISSN 0929-5666
Publication date 1997-01-01
Sub-type Article (original research)
DOI 10.1023/A:1008878017315
Volume 4
Issue 2
Start page 79
End page 84
Total pages 6
Language eng
Abstract alpha-Aspartyl-containing cyclic pentapeptides were synthesised in high yields using a strategy that maintained fluorenylmethyl protection on the aspartic acid side chain during chain assembly, resin cleavage and cyclisation of the linear precursors. Tetra-n-butylammonium fluoride treatment of the fluorenylmethyl-protected cyclic peptides catalysed imide formation, whereas piperidine-induced deprotection resulted in good yields of the target cyclic peptides.
Keyword Biochemistry & Molecular Biology
Aspartimide Formation
Beta-peptides
Cyclic Peptides
Fluorenylmethyl Protection
Solid-phase
Succinimide Formation
Amino-acids
Isomerization
Derivatives
Deamidation
Asparaginyl
Degradation
Chemistry
Residues
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 14 Aug 2007, 02:47:35 EST